Skeletal muscle atrophy and increased intramuscular fat after incomplete spinal cord injury
Skeletal muscle atrophy and increased intramuscular fat after incomplete spinal cord injury
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DOI：
10.1038/sj.sc.3101968
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发表时间：
2007-04-01
期刊：
影响因子：
2.2
通讯作者：
Dudley, G. A.
中科院分区：
文献类型：
--
作者：
Gorgey, A. S.;Dudley, G. A.
研究设计：横断面和纵向设计。目的：( 1) 不完全脊髓损伤 ( SCI ) 后 6 周，校正大腿肌肉群中的肌内脂肪 ( IMF ) 后，量化骨骼肌横截面积 ( CSA )，( 2 ) 监测初始测量后 3 个月后肌肉 CSA 和 IMF 的变化。 地点：美国佐治亚州雅典市学术机构。 方法： 六名不完全 SCI 患者（28 +/- 4 岁，178 +/- 5 cm 和 78 +/- 6 kg，平均值 +/- SE，C7 至 L3，美国脊柱损伤协会 B 或 C）在初次测量后 5 +/- 1 周和 3 个月进行了测试。对两条大腿拍摄了 T1 加权磁共振图像。六名身体健全 (AB) 对照的年龄、性别、身高和体重相匹配（29 +/- 4 岁，四名男性和两名女性受试者，179 +/- 5 cm 和 77 +/- 6 kg）。结果：受伤后 6 周，不完全 SCI 中的肌肉 CSA 为 82 +/- 4 cm(2)，AB 对照中为 123 +/- 21 cm(2)（ P = 0.04）。在不完整的 SCI 和 AB 对照中，IMF CSA 分别为 5.2 +/- 1.3 和 2.3 +/- 0.6 cm(2) ( P = 0.03)。 SCI 组的相对 IMF 比 AB 对照组高出三倍（P = 0.03）（5.8 +/- 1.4 与 2.0 +/- 0.6%）。 3 个月后，与初始测量值相比，SCI 组的 IMF 增加了 26%（P = 0.02）。结论：与 AB 对照组相比，SCI 组受伤后 6 周骨骼肌萎缩与更大的 IMF 积累相关。此外，在不完整的 SCI 中，IMF 随着时间的推移持续增加。
Study design: Cross-sectional and longitudinal design.Objectives: ( 1) To quantify skeletal muscle cross-sectional area ( CSA) after correcting for intramuscular fat ( IMF) in thigh muscle groups 6 weeks after incomplete spinal cord injury ( SCI), ( 2) to monitor the changes in muscle CSA and IMF after 3 months from the initial measurement.Setting: Academic institution Athens, GA, USA.Methods: Six incomplete SCI patients ( 28 +/- 4 years, 178 +/- 5 cm and 78 +/- 6 kg, mean +/- SE, C7 to L3, American Spinal Injury Association B or C) were tested at 5 +/- 1 weeks and 3 months after the initial measurement. T1-weighted magnetic resonance images were taken of both thighs. Six able-bodied ( AB) controls were matched in age, sex, height and weight ( 29 +/- 4 years, four male and two female subjets, 179 +/- 5 cm and 77 +/- 6 kg).Results: At 6 weeks post-injury, muscle CSA was 82 +/- 4 cm(2) in incomplete SCI and 123 +/- 21 cm(2) in AB controls ( P = 0.04). IMF CSA was 5.2 +/- 1.3 and 2.3 +/- 0.6 cm(2) in incomplete SCI and AB controls, respectively ( P = 0.03). Relative IMF was three-fold higher ( P = 0.03) in the SCI group versus AB controls ( 5.8 +/- 1.4 versus 2.0 +/- 0.6%). After 3 months, IMF increased 26% in the SCI group compared to the initial measurement ( P = 0.02).Conclusions: Skeletal muscle atrophy is associated with greater IMF accumulation in SCI group 6 weeks post-injury compared to AB controls. Moreover, IMF continues to increase over time in incomplete SCI.