Anorexia nervosa and anorexic-like syndromes in a population-based female twin sample.
Anorexia nervosa and anorexic-like syndromes in a population-based female twin sample.
复制标题
基于人群的女性双胞胎样本中的神经性厌食症和厌食样综合征。
DOI：
10.1176/ajp.152.1.64
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kendler,KS
中科院分区：
文献类型：
--
作者：
Walters,EE;Kendler,KS
作者探讨了神经性厌食症的流行病学特征和危险因素，并研究了狭义的神经性厌食症和厌食症样syndromes. Methods之间的关系，结构化的访谈进行了管理，以人口为基础的样本的2,163名女性双胞胎。神经性厌食症的诊断计算机算法（“计算机窄”）和狭窄和广泛的临床definitions.ResultsLifetime患病率估计为0.51%，1.62%，和3.70%，分别获得了计算机窄，临床狭窄，临床广泛的诊断。饮食状况、父母受教育年限、低自尊、高神经质和母亲过度保护与神经性厌食症显著相关。合并症的模式和与流行病学危险因素的关系都表明狭义和广义的腹泻综合征之间的病因连续性。患有神经性厌食症的双胞胎的同卵双胞胎患神经性厌食症、神经性贪食症、重度抑郁症和当前低体重指数的风险显著较高。神经性厌食症和抑郁症，神经性贪食症，广泛性焦虑症，酗酒，恐惧症，和panic disorder.ConclusionsThe作者的分析支持一个频谱的女性厌食症样综合征的假设。这些综合征是家族性的，与抑郁症和神经性贪食症有共同的家族病因。
ObjectiveThe authors explored the epidemiologic characteristics and risk factors of anorexia nervosa and examined the relationship between narrowly defined anorexia nervosa and anorexia-like syndromes.MethodStructured interviews were administered to a population-based sample of 2,163 female twins. Anorexia nervosa was diagnosed by computer algorithm (" computer narrow") and by narrow and broad clinical definitions.ResultsLifetime prevalence estimates of 0.51%, 1.62%, and 3.70% were obtained for the computer narrow, clinical narrow, and clinical broad diagnoses, respectively. Dieting status, greater number of years of parental education, low self-esteem, high levels of neuroticism, and maternal overprotectiveness were significantly associated with anorexia nervosa. Both the pattern of comorbidity and the relationship to epidemiologic risk factors suggested an etiologic continuity between narrowly and broadly defined anorexic syndromes. Co-twins of twins with anorexia nervosa were at significantly higher risk for lifetime anorexia nervosa, bulimia nervosa, major depression, and current low body mass index. Significant comorbidity was found between anorexia nervosa and major depression, bulimia nervosa, generalized anxiety disorder, alcoholism, phobias, and panic disorder.ConclusionsThe authors' analyses support the hypothesis of a spectrum of anorexic-like syndromes in women. These syndromes are familial and share familial etiologic factors with major depression and bulimia nervosa.