Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
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DOI：
10.1136/thorax.57.10.875
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发表时间：
2002-10-01
期刊：
影响因子：
10
通讯作者：
Pavord, ID
中科院分区：
文献类型：
--
作者：
Green, RH;Brightling, CE;Pavord, ID
背景资料：关于哮喘是单一疾病还是异质性疾病的争论仍然没有解决，尽管病理学研究，主要是在少数受试者中使用纤维支气管镜，强调了不同临床表型之间的相似性。采用诱导痰对34名正常对照和259名接受第1- 4步治疗的有症状哮喘成人的下气道炎症进行了非侵入性评估。英国胸科学会（BTS）的3项指南。一个亚组的49例患者治疗所需的β（2）受体激动剂，只有谁符合BTS标准的一步在治疗前和2个月后，吸入布地奈德400 μ g，每日两次治疗进行了研究。60例患者的一个亚组具有独特的痰细胞特征，中性粒细胞计数高于我们的正常范围（>65.3%），痰嗜酸性粒细胞计数正常（
Background: The debate as to whether asthma is a single or heterogeneous disease remains unresolved although pathological studies, mostly using fibreoptic bronchoscopy on small numbers of subjects, have emphasised the similarities between different clinical phenotypes.Methods: Lower airway inflammation was assessed non-invasively using induced sputum in 34 normal controls and 259 adults with symptomatic asthma receiving treatment at steps 1-3 of the British Thoracic Society (BTS) guidelines. A subgroup of 49 patients treated with as required beta(2) agonists only who met BTS criteria for a step up in treatment were studied before and 2 months after treatment with inhaled budesonide 400 mug twice daily.Results: There was considerable heterogeneity in induced sputum cell counts, particularly in non-atopic patients. A subgroup of 60 patients had a distinctive sputum cell profile with a neutrophil count higher than our normal range (>65.3%) and a normal sputum eosinophil count (