SALT TASTE TRANSDUCTION OCCURS THROUGH AN AMILORIDE-SENSITIVE SODIUM-TRANSPORT PATHWAY
SALT TASTE TRANSDUCTION OCCURS THROUGH AN AMILORIDE-SENSITIVE SODIUM-TRANSPORT PATHWAY
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DOI：
10.1126/science.6691151
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
DESIMONE, JA
中科院分区：
文献类型：
--
作者：
HECK, GL;MIERSON, S;DESIMONE, JA
哺乳动物对氯化钠味觉传导的一个重要早期事件是Na+通过味蕾顶端区域的特定转运途径。钠离子转运阻滞剂阿米洛利可显著降低NaCl作用于大鼠舌背上皮体外制备的粘膜表面所引起的内向电流。阿米洛利是一种特异性的鼓索对NaCl的反应阻滞剂，但不是KCl。Na和K味觉系统在很大程度上是独立的外周水平，经典的离子味觉受体实际上是一个特定的运输途径，允许阳离子进入味蕾细胞，从而传播去极化电流。
An important early event in mammalian gustatory transduction with respect to NaCl was the passage of Na+ through specific transport pathways in the apical region of the taste bud. The inward current caused by NaCl placed on the mucosal surface of an in vitro preparation of rat dorsal lingual epithelium can be substantially reduced by the blocker of Na ion transport, amiloride. Amiloride is a specific blocker of the chorda tympani response to NaCl, but not to KCl. Na and K gustatory systems are largely independent at the peripheral level; classical ion taste receptor is actually a specific transport pathway permitting the cation to enter the taste-bud cell and thereby to spread depolarizing current.