Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA.
Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA.
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小鼠 Src 样接头蛋白 (Slap) 基因及其假定的人类同源物 SLA 的染色体定位。
DOI：
10.1006/geno.1995.1289
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Pandey,A
中科院分区：
文献类型：
--
作者：
Angrist,M;Wells,DE;Chakravarti,A;Pandey,A
含有Src-homology 2 （SH2）和Src-homology 3 （SH3）结构域的分子是信号转导途径的关键组成部分，可将源自细胞表面的信号传递到细胞内部。Src-like adapter protein （SLAP）是最近发现的一种结合活化Eck受体蛋白酪氨酸激酶的适配器蛋白。尽管SLAP与非受体酪氨酸激酶Src家族的SH3和SH2结构域具有惊人的同源性，但它不包含酪氨酸激酶催化结构域。在本报告中，通过连锁分析将Slap基因定位在小鼠第15染色体上，而通过一组体细胞杂交鉴定了其假定的人类同源基因（SLA），并将其定位在人类8q22.3-qter上。
Molecules containing Src-homology 2 (SH2) and Src-homology 3 (SH3) domains are critical components of signal transduction pathways that serve to relay signals originating from the cell surface to the interior of the cell. Src-like adapter protein (SLAP) is a recently described adapter protein that binds activated the Eck receptor protein-tyrosine kinase. Although SLAP bears a striking homology to the SH3 and SH2 domains of the Src family of nonreceptor tyrosine kinases, it does not contain a tyrosine kinase catalytic domain. In this report, the Slap gene was mapped by linkage analysis to mouse chromosome 15, while its putative human homolog (SLA) was identified and mapped to human 8q22.3-qter using a panel of somatic cell hybrids.