Impact of antiretroviral dosing frequency and pill burden on adherence among newly diagnosed, antiretroviral-naive HIV patients
Impact of antiretroviral dosing frequency and pill burden on adherence among newly diagnosed, antiretroviral-naive HIV patients
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DOI：
10.1258/ijsa.2011.011292
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发表时间：
2012-05-01
影响因子：
1.4
通讯作者：
Giordano, T. P.
中科院分区：
文献类型：
--
作者：
Buscher, A.;Hartman, C.;Giordano, T. P.
关于抗逆转录病毒疗法(ART)方案因素对未接受抗逆转录病毒疗法(ART)治疗的HIV患者坚持当代每日一至两次方案的影响的数据很少。在一项前瞻性观察队列研究中，99名新诊断的患者完成了视觉模拟量表，以评估他们对ART的依从性。用Brown-Mod中位数检验比较ART类型和给药频率的依从性。每天服用一次的参与者的依从性(n=70，99.5%)高于每天服用两次的参与者(n=29，94%；P=0.01)。接受固定剂量联合用药的受试者依从性(n=34,100%)与每日服用一次两片或两片以上药物的受试者(n=36，99.3%；P=0.34)无差异。在一组新诊断为ART的幼稚患者中，每天服用一次ART的依从性高于每天服用两次。每日一次服药方案中的服药负担并不能预测依从性，这表明比服药负担更多的因素应该推动服药方案的选择。
There are few data on the impact of antiretroviral therapy (ART) regimen factors on adherence in ART-naive HIV patients on contemporary once- or twice-daily regimens. Ninety-nine newly diagnosed patients in a prospective observational cohort study completed a visual analogue scale to assess their ART adherence. Adherence by type of ART and dosing frequency were compared by Brown-Mood median tests. Participants taking once-daily regimens had higher adherence (n = 70, 99.5%) compared with participants taking twice-daily regimens (n = 29, 94%; P = 0.01). Adherence of participants taking the fixed dose combination efavirenz-emtricitabine-tenofovir (n = 34, 100%) compared with those taking once-daily regimens of two or more pills was no different (n = 36, 99.3%; P = 0.34). Among a cohort of newly diagnosed ART-naive patients, once-daily dosing of ART resulted in higher adherence than twice-daily dosing. Pill burden among once-daily regimens did not predict adherence, suggesting that factors oilier than pill burden should drive regimen selection.