The sheep genome illuminates biology of the rumen and lipid metabolism.
The sheep genome illuminates biology of the rumen and lipid metabolism.
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DOI：
10.1126/science.1252806
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发表时间：
2014-06-06
期刊：
影响因子：
--
通讯作者：
Dalrymple BP
中科院分区：
文献类型：
--
作者：
Jiang Y;Xie M;Chen W;Talbot R;Maddox JF;Faraut T;Wu C;Muzny DM;Li Y;Zhang W;Stanton JA;Brauning R;Barris WC;Hourlier T;Aken BL;Searle SMJ;Adelson DL;Bian C;Cam GR;Chen Y;Cheng S;DeSilva U;Dixen K;Dong Y;Fan G;Franklin IR;Fu S;Guan R;Highland MA;Holder ME;Huang G;Ingham AB;Jhangiani SN;Kalra D;Kovar CL;Lee SL;Liu W;Liu X;Lu C;Lv T;Mathew T;McWilliam S;Menzies M;Pan S;Robelin D;Servin B;Townley D;Wang W;Wei B;White SN;Yang X;Ye C;Yue Y;Zeng P;Zhou Q;Hansen JB;Kristensen K;Gibbs RA;Flicek P;Warkup CC;Jones HE;Oddy VH;Nicholas FW;McEwan JC;Kijas J;Wang J;Worley KC;Archibald AL;Cockett N;Xu X;Wang W;Dalrymple BP
绵羊（Ovis aries）是肉、奶和羊毛纤维的主要来源，是一类独特的动物，它们有一个专门的消化器官——瘤胃，负责对植物物质进行初步消化。我们开发并分析了来自40个不同组织的高质量参考羊基因组和转录组。我们发现了与瘤胃进化相关的角蛋白交联蛋白编码的高表达基因。我们还确定了参与脂质代谢的基因，这些基因被扩增和/或改变了组织表达模式。这可能是由于皮肤屏障脂质的变化，脂质代谢和羊毛合成之间的相互作用，以及与非反刍动物相比，反刍动物中挥发性脂肪酸的作用增加。
Sheep (Ovis aries) are a major source of meat, milk and fiber in the form of wool, and represent a distinct class of animals that have a specialized digestive organ, the rumen, which carries out the initial digestion of plant material. We have developed and analyzed a high quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants, compared to non-ruminant animals.
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DOI：
10.4161/derm.3.2.15472
发表时间：
2011-04
期刊：
Dermato-endocrinology
影响因子：
--
作者：
Radner FP;Grond S;Haemmerle G;Lass A;Zechner R
通讯作者：
Zechner R
影响因子：
4.2
作者：
INGLE, DL;BAUMAN, DE;GARRIGUS, US
通讯作者：
GARRIGUS, US
DOI：
10.1073/pnas.231489198
发表时间：
2001-11-06
影响因子：
11.1
作者：
Marshall, D;Hardman, MJ;Byrne, C
通讯作者：
Byrne, C
影响因子：
30.8
作者：
Clop, Alex;Marcq, Fabienne;Georges, Michel
通讯作者：
Georges, Michel
影响因子：
4.8
作者：
Cheng, D;Nelson, TC;Feder, JN
通讯作者：
Feder, JN