Pochonins K-P: new radicicol analogues from Pochonia chlamydosporia var. chlamydosporia and their WNT-5A expression inhibitory activities
Pochonins K-P: new radicicol analogues from Pochonia chlamydosporia var. chlamydosporia and their WNT-5A expression inhibitory activities
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DOI：
10.1016/j.tet.2009.02.027
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发表时间：
2009-04-25
期刊：
影响因子：
2.1
通讯作者：
Kawashima, Akira
中科院分区：
文献类型：
--
作者：
Shinonaga, Hideki;Kawamura, Yoji;Kawashima, Akira
WNT-5A是一种分泌性糖蛋白，与毛乳头细胞的增殖有关。为了开发毛发生长刺激剂，我们一直在寻找WNT-5A表达的抑制剂，并且已经鉴定了活性化合物，根赤壳素（1），并分离了六种新的根赤壳素类似物，pochonins K-P（2-7），以及十种已知的根赤壳素类似物，包括monorden analogue-1（8），pochonin E（9）和pochonin F（10），来自真菌厚垣孢Pochonia chlamydosporia TF-0480的培养液。本文报道了2-7的结构鉴定，8-10的立体化学测定，以及它们对WNT-5A的生物活性。(C)2009爱思唯尔有限公司保留所有权利。
WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. To develop a hairgrowth stimulant, we have been searching for an inhibitor of WNT-5A expression, and have identified an active compound, radicicol (1), and isolated six new radicicol analogues, pochonins K-P (2-7), together with ten known radicicol analogues, including monorden analogue-1 (8), pochonin E (9), and pochonin F (10), from a culture broth of the fungus Pochonia chlamydosporia TF-0480. This report describes the structural elucidation of 2-7, determination of the stereochemistries of 8-10, and their biological activities against WNT-5A. (C) 2009 Elsevier Ltd. All rights reserved.