Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control - The ARIC study
Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control - The ARIC study
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DOI：
10.1161/01.str.27.12.2262
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发表时间：
1996-12-01
期刊：
影响因子：
8.3
通讯作者：
Tyroler, HA
中科院分区：
文献类型：
--
作者：
Liao, DP;Cooper, L;Tyroler, HA
背景和目的脑白质病变（WML）可能由脑灌注不足或缺血引起。我们研究了WML与血压、高血压及其治疗和控制的关系。方法对社区动脉粥样硬化风险研究（ARIC）中年龄在55 ~ 72岁的1920名参与者进行随机抽样。自旋密度1.5-T MRI扫描图像从0（正常）到9（最严重的WML）编码。高血压定义为收缩压或舒张压大于或等于140/90 mm Hg或使用抗高血压药物。结果WML 0 ~ 2级和3 ~ 9级患者的比例分别为：血压正常者为92.4%和7.6%，而所有高血压患者为83%和17% (P
Background and Purpose White matter lesions (WML) may result from cerebral hypoperfusion or ischemia. We investigated the association of WML with blood pressure, hypertension, and its treatment and control.Methods A random sample of 1920 participants aged 55 to 72 years in the Atherosclerosis Risk in Communities Study (ARIC) was examined. Spin-density 1.5-T MRI scan images were coded from 0 for normal to 9 for most severe WML. Hypertension was defined as systolic or diastolic pressure greater than or equal to 140/90 mm Hg or use of antihypertensive medication.Results The percentages of persons with WML grades 0 through 2 and 3 through 9, respectively, were as follows: normotensive, 92.4% and 7.6%, versus all hypertensive subjects, 83% and 17% (P