Conformation of [Leu5]enkephalin from X-ray diffraction: features important for recognition at opiate receptor.
Conformation of [Leu5]enkephalin from X-ray diffraction: features important for recognition at opiate receptor.
复制标题
X 射线衍射的 [Leu5] 脑啡肽构象：对于阿片受体识别很重要的特征。
作者：
D. Smith;J. Griffin
[Leu 5]脑啡肽的构象由酪氨酸和苯丙氨酸之间的反平行氢键稳定的Tyr-Gly-Gly-Phe β弯曲产生。基于所观察到的结构与已知的阿片激动剂的结构的比较，三个亲水性区域和两个疏水性区域已被鉴定为有助于在阿片受体位点识别分子。
The conformation of [Leu5]enkephalin is produced by a Tyr-Gly-Gly-Phe beta bend stabilized by antiparallel hydrogen bonding between tyrosine and phenylalanine. On the basis of a comparison of the observed structure with the structure of known opiate agonists, three hydrophilic and two hydrophobic regions have been identified as contributing to the recognition of the molecule at the opiate receptor site.