Recent advances in high-throughput molecular marker identification for superficial and invasive bladder cancers
Recent advances in high-throughput molecular marker identification for superficial and invasive bladder cancers
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DOI：
10.2741/2211
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发表时间：
2007-01-01
影响因子：
3.1
通讯作者：
Orntoft, Torben Falck
中科院分区：
文献类型：
--
作者：
Dyrskjot, Lars;Zieger, Karsten;Orntoft, Torben Falck
膀胱癌是工业化国家的第五大常见肿瘤。由于这种疾病的浅表形式经常复发，膀胱癌被列为最常见的癌症之一。尽管有大量膀胱癌肿瘤标志物的描述，但没有一个单独对膀胱癌的治疗做出贡献。然而，用于同时评估大量标志物的高通量技术的发展使得肿瘤能够被分类为临床上相关的分子亚群，而不是通过病理分类。在此，我们就高通量分子标记在浅表性和浸润性膀胱癌分子标记鉴定方面的最新进展作一综述。
Bladder cancer is the fifth most common neoplasm in industrialized countries. Due to frequent recurrences of the superficial form of this disease, bladder cancer ranks as one of the most common cancers. Despite the description of a large number of tumor markers for bladder cancers, none have individually contributed to the management of the disease. However, the development of high-throughput techniques for simultaneous assessment of a large number of markers has allowed classification of tumors into clinically relevant molecular subgroups beyond those possible by pathological classification. Here, we review the recent advances in high-throughput molecular marker identification for superficial and invasive bladder cancers.