Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission.
Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission.
复制标题
孕期母亲吸毒与母亲艾滋病毒培养阳性和围产期艾滋病毒传播之间的关系。
DOI：
10.1097/00002030-199603000-00006
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Hanson,IC
中科院分区：
文献类型：
--
作者：
Rodriguez,EM;Mofenson,LM;Chang,BH;Rich,KC;Fowler,MG;Smeriglio,V;Landesman,S;Fox,HE;Diaz,C;Green,K;Hanson,IC
目的：评价药物使用与产妇分娩时HIV培养阳性和围产期HIV传播的关系。设计：多中心前瞻性队列研究。设置：美国5个城市的产科和儿科诊所。研究对象：530名感染HIV的孕妇及其婴儿。主要观察指标：采用多因素Logistic回归分析，评价分娩时母体HIV培养阳性和围产期HIV传播与“硬毒品”使用(可卡因、海洛因/鸦片类药物、美沙酮、注射毒品中的一种或多种)和尿毒学的关系。结果：42%的妇女在孕期使用硬毒品。艾滋病毒培养阳性的可能性增加与产前硬毒品的使用显著相关[优势比(OR)，3.081；在艾滋病毒感染妇女中，有29%的CD+淋巴细胞的母亲使用可卡因(OR，2.98)。在调整了分娩时母体培养阳性、CD4+淋巴细胞百分率和胎龄后，在胎膜破裂4小时的妇女中，硬毒品的传播风险显著增加。结论：根据自我报告和尿毒学，WITS队列中母亲总体硬毒品使用和可卡因使用与分娩时母体HIV文化阳性相关，母体硬毒品使用与围产期传播相关。
Objective: To evaluate the relationship of drug use with maternal HIV culture positivity at delivery and perinatal HIV transmission.Design: Multicenter prospective cohort study.Setting: Obstetric and pediatric clinics in five cities in the United States.Participants: Five hundred and thirty HIV-infected pregnant women and their infants.Main outcome measures: Multivariate logistic regression was used to evaluate the association of'hard drug'use (one or more of the following: cocaine, heroin/opiates, methadone, injecting drug use) assessed by self-report and urine toxicology with positive maternal HIV culture at delivery and perinatal HIV transmission.Results: Forty-two per cent of women used hard drugs during pregnancy. Increased probability of a positive maternal delivery HIV culture was significantly associated with prenatal hard drug use [odds ratio (OR), 3.081 and maternal cocaine use (OR, 2.98) among HIV-infected women with> 29% CD4+ lymphocytes. After adjusting for maternal culture positivity at delivery, CD4+ lymphocyte percentage and gestational age, significantly greater transmission risk was observed with hard drug use among women with membrane rupture> 4 h.Conclusions: On the basis of self-report and urine toxicology, overall maternal hard drug use and cocaine use in the WITS cohort were associated with maternal HIV culture positivity at delivery, and maternal hard drug use was associated with perinatal transmission.