[Energy metabolism pathway related genes and adaptive evolution of tumor cells].
[Energy metabolism pathway related genes and adaptive evolution of tumor cells].
复制标题
DOI：
10.3724/sp.j.1141.2012.06557
复制
发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Jia Liu;Q. Kong
中科院分区：
文献类型：
--
作者：
Jia Liu;Q. Kong
The proliferation of tumor cells is an extremely energy-consuming process. However, different from normal cells, tumor cells generate energy via glycolysis even under aerobic conditions, which is one of the ten hallmarks of tumor cells. The switch of energy metabolism results in a series of physiological changes in tumor cells, including rapid generation of ATP and abundant biomass for cell proliferation, which form the basis of tumor cells to successfully adapt to their extreme microenvironment (e.g. lack of oxygen). In this review, we will introduce recent progress in studying somatic mutations on the energy metabolism related genes in tumors, with special focus on the potential factors involving in the "switch" and to decipher the genetic adaptive footprint of the "switch" from the angle of molecular evolution.
