Escitalopram and paroxetine in the treatment of generalised anxiety disorder - Randomised, placebo-controlled, double-blind study
Escitalopram and paroxetine in the treatment of generalised anxiety disorder - Randomised, placebo-controlled, double-blind study
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DOI：
10.1192/bjp.bp.105.012799
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发表时间：
2006-09-01
影响因子：
10.5
通讯作者：
Maehlum, Eli
中科院分区：
文献类型：
--
作者：
Baldwin, David S.;Huusom, Anna Karina Trap;Maehlum, Eli
背景目前尚不确定是否更高剂量的选择性5-羟色胺再摄取抑制剂对广泛性焦虑障碍有更大的疗效。目的评估不同剂量的艾司西酞普兰对广泛性焦虑障碍的疗效。方法随机、双盲、安慰剂对照、固定剂量、平行组、12周研究，681例患者：安慰剂组（n=139）;艾司西酞普兰组（n=134）;结果艾司西酞普兰10 mg和20 mg组主要疗效指标的平均变化大于安慰剂组，艾司西酞普兰10 mg组疗效优于帕罗西汀20 mg组。在某些时间点，帕罗西汀在某些次要指标上上级安慰剂。与安慰剂相比，艾司西酞普兰20 mg和帕罗西汀组因不良事件退出的患者更多。结论艾司西酞普兰治疗广泛性焦虑症有效，20 mg/d与10 mg/d相比无显著上级优势。艾司西酞普兰10 mg比帕罗西汀更有效。
Background It is uncertain whether higher doses of selective serotonin reuptake inhibitors have greater efficacy in generalised anxiety disorder.Aims To assess the efficacy of different doses of escitalopram in generalised anxiety disorder.Method Randomised, double-blind, placebo-controlled, fixed-dose, parallel-group, 12-week study, with 681 patients: placebo (n=139); escitalopram, 5 mg/day, (n=134); 10 mg/day (n=136); 20 mg/day (n=133); paroxetine, 20 mg/day (n=139).Results Mean change in the primary efficacy measure was greater with escitalopram 10 and 20 mg than with placebo; 10 mg was more efficacious than paroxetine. Paroxetine was superior to placebo on some secondary measures, at some time points. Compared with placebo, more patients withdrew because of adverse events with escitalopram 20 mg and Paroxetine.Conclusions Escitalopram was efficacious in generalised anxiety disorder, 20 was not significantly superior to 10 mg/day. Escitalopram 10 mg was more efficacious than paroxetine.