Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men.
Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men.
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DOI：
10.1017/s000711451600458x
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Sekikawa A
中科院分区：
文献类型：
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作者：
Ahuja V;Miura K;Vishnu A;Fujiyoshi A;Evans R;Zaid M;Miyagawa N;Hisamatsu T;Kadota A;Okamura T;Ueshima H;Sekikawa A
木醇是饮食中异黄酮类大豆苷元的代谢物，是由肠道细菌在某些人体内的作用产生的，这些人被称为木马素生产者。它被认为比饮食中的异黄酮具有更强的动脉粥样硬化保护作用。我们在日本男性中研究了饮食异黄酮类和木马生产状态与冠状动脉钙化(CAC)的横截面关联，CAC是冠状动脉粥样硬化的生物标记物。对2004年至2007年招募的272名年龄在40-49岁的日本男性进行了基于人群的样本检测，以检测血清异黄酮类、血清木醇、CAC和其他因素。马匹生产者被归类为血清马匹水平为83 NM的个人。冠状动脉钙化的存在被定义为冠状动脉钙化积分≥10个阿加斯顿单位。用多元Logistic回归分析膳食中异黄酮类和木马类物质与CAC的关系。饲料中异黄酮类、木质素和CAC的中位数分别为512.7(四分位数范围194·1,1170·0)、9.1(IQR 0·10，33·1)和0·0(IQR 0·0，1·0)NM。CAC和产马马者的患病率分别为9.6%和16.0%。饮食中的异黄酮类与CAC的相关性不显著。经多因素调整后，产马马者与非产马马者发生CAC的OR值为0·10(95%CI为0·01，0·90，P<；0·04)。在日本男性中，生产木马醇的人的CAC显著低于不生产木马的人，但饮食中的异黄酮类与CAC之间没有显著的关联，这表明在日本男性中，木马可能是异黄酮类抗动脉粥样硬化特性的关键因素。这一发现必须在更大规模的研究或临床试验中得到证实，这些研究或临床试验现在可以作为膳食补充剂。
Equol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary isoflavones. We examined a cross-sectional association of dietary isoflavones and equol-producer status with coronary artery calcification (CAC), a biomarker of coronary atherosclerosis, among men in Japan. A population-based sample of 272 Japanese men aged 40–49 years recruited from 2004 to 2007 was examined for serum isoflavones, serum equol, CAC and other factors. Equol-producers were classified as individuals having a serum level of equol >83 nM. The presence of CAC was defined as a coronary Ca score ≥10 Agatston units. The associations of dietary isoflavones and equol-producers with CAC were analysed using multiple logistic regression. The median of dietary isoflavones, equol and CAC were 512·7 (interquartile range (IQR) 194·1, 1170·0), 9·1 (IQR 0·10, 33·1) and 0·0 (IQR 0·0, 1·0) nM, respectively. Prevalence of CAC and equol-producers was 9·6 and 16·0 %, respectively. Dietary isoflavones were not significantly associated with CAC. After multivariable adjustment, the OR for the presence of CAC in equol-producers compared with equol non-producers was 0·10 (95 % CI 0·01, 0·90, P < 0·04). Equol-producers had significantly lower CAC than equol non-producers, but there was no significant association between dietary isoflavones and CAC, suggesting that equol may be a key factor for atheroprotective properties of isoflavones in Japanese men. This finding must be confirmed in larger studies or clinical trials of equol that is now available as a dietary supplement.