Elastic properties of the young aorta: ex vivo perfusion experiments in a porcine model
Elastic properties of the young aorta: ex vivo perfusion experiments in a porcine model
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DOI：
10.1093/ejcts/ezu438
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发表时间：
2015-08-01
影响因子：
3.4
通讯作者：
Schlensak, Christian
中科院分区：
文献类型：
--
作者：
Krueger, Tobias;Grigoraviciute, Akvile;Schlensak, Christian
目的：研究健康猪主动脉的局部和方向性顺应性/扩张性。方法：使用自制的脉冲复制器，在一定的血流动力学参数下，体外灌流完整新鲜猪主动脉(n=11)。结果：脉搏复制器能够以任意血流动力学参数对整个主动脉进行灌流，生成生理脉搏曲线。主动脉顺应性与压力有关，我们观察到压力与扩张在5-200毫米汞柱范围内呈线性关系；然而，在200毫米汞柱以上，猪主动脉表现为非弹性。升主动脉的周向顺应性最高(24%/100 mm Hg)，而弓部(18%/100 mm Hg)和降主动脉(15%/100 mm Hg)的顺应性显著降低(P<；0.05)。升主动脉纵向顺应性最高，明显超过周向顺应性。升主动脉和主动脉弓外曲的顺应性显著高于这两个部位的内曲顺应性(升主动脉30%/100vs23%/100 mm Hg和弓部20%/100vs9%/100 mm Hg)。结论：升主动脉的纵向顺应性，尤其是外曲，是温克塞尔效应的主要原因。升主动脉延长和明显成角等病理改变增加了外曲的应力，可能是主动脉夹层发生发展的重要因素。
OBJECTIVES: To investigate the regional and directional compliance/distensibility of the healthy aorta.METHODS: Complete fresh porcine aortas (n = 11) were perfused ex vivo under defined haemodynamic parameters using a custom-made pulse duplicator. Both circumferential and longitudinal compliance were measured optically.RESULTS: The pulse duplicator was able to perfuse the entire aorta with arbitrary haemodynamic parameters, generating a physiological pulse curve. Aortic compliance is pressure dependent, as we observed a linear relationship between pressure and distension in the range of 5-200 mmHg; however, above 200 mmHg, the porcine aorta behaved in an inelastic manner. Circumferential compliance was highest in the ascending aorta (24%/ 100 mmHg) but significantly (P < 0.05) decreased in both the arch (18%/ 100 mmHg) and the descending aorta (15%/100 mmHg). Longitudinal compliance was highest in the ascending aorta and clearly exceeded circumferential compliance. Compliance was significantly (P < 0.05) higher in the outer curvatures of the ascending aorta and the aortic arch compared with the compliance of the inner curvature at these locations (30%/100 vs 23%/100 mmHg in the ascending aorta and 20%/ 100 vs 9%/100 mmHg in the arch, respectively).CONCLUSIONS: Longitudinal compliance of the ascending aorta, particularly the outer curvature, is predominantly responsible for the 'Windkessel effect'. Pathological changes such as elongation and pronounced angulation of the ascending aorta increase stress on the outer curvature and may be important factors in the development of aortic dissection.