Helicobacter pylori infection and development of gastric cancer in Korea
Helicobacter pylori infection and development of gastric cancer in Korea
复制标题
DOI：
10.1097/mcg.0b013e318046eac3
复制
发表时间：
2008-05-01
影响因子：
2.9
通讯作者：
Song, In Sung
中科院分区：
文献类型：
--
作者：
Kim, Nayoung;Park, Ran Young;Song, In Sung
背景和目的：幽门螺杆菌感染被认为是进展到癌前状态或胃癌的主要驱动力。本研究旨在探讨H. pylori感染对胃癌发生发展的影响，并确定H.方法：对1790名接受胃镜检查和H. 1992年至1998年进行的幽门螺杆菌检测H.幽门螺杆菌阳性和根除状态对胃癌的发展进行了analysed.Results：胃癌发展的研究队列中的5个在平均随访期为9.4年。所有患者均为H. pylori感染，5例中有4例在研究入组时患有胃窦肠上皮化生（IM）。这5例患者中有1例在诊断胃癌时处于根除状态，在进行根除治疗前有组织学IM。胃癌的发生率在IM存在时是IM不存在时的10.9倍。pylori感染与肠化生的关系以及肠化生与胃癌发生的关系。此外，我们的研究结果表明，慢性H。在韩国，幽门螺杆菌感染似乎是胃癌发生的一个重要危险因素。pylori仍然很高。本研究提示，预防胃癌，H.幽门螺杆菌根除最好在IM发展之前进行。
Background and Aim: Infection of Helicobacter pylori is viewed as a major driver of progression to the precancerous state or to gastric cancer. This study was performed to investigate the effect of H. pylori infection on gastric cancer development and to determine to what extent H. pylori eradication is likely to reduce the prevalence of gastric cancer.Methods: Gastric cancer development was investigated in 1790 Korean subjects who underwent gastroscopy and H. pylori testing between 1992 and 1998. The effects of H. pylori-positive and eradicated states on gastric cancer development were analyzed.Results: Gastric cancer developed in 5 of the study cohort during a mean follow-up period of 9.4 years. All of these patients were positive for H. pylori infection, and 4 of the 5 had antral intestinal metaplasia (IM) at the time of study enrollment. One of these 5 patients was in an eradicated state when the gastric cancer was diagnosed, and had histologic IM before eradication therapy was performed. Gastric cancer was found to develop 10.9 times more frequently in the presence of IM than in its absence.Conclusions: The present study shows a close relationship between H. pylori infection and IM, and between IM and the development of gastric cancer. In addition, our finding suggests that chronic H. pylori infection looks like an important risk factor for the development of gastric cancer in Korea, where the prevalence of H. pylori remains high. This study indicates that to prevent gastric cancer H. pylori eradication is best performed before the development of IM.