A community-derived outbreak of adenovirus type 3 in children in Taiwan between 2004 and 2005
A community-derived outbreak of adenovirus type 3 in children in Taiwan between 2004 and 2005
复制标题
DOI：
10.1002/jmv.21045
复制
发表时间：
2008-01-01
影响因子：
12.7
通讯作者：
Kao, Chuan-Liang
中科院分区：
文献类型：
--
作者：
Chang, Sui-Yuan;Lee, Chun-Nan;Kao, Chuan-Liang
摘要2004年11月至2005年2月间，在台湾北方发生一次儿童呼吸道腺病毒感染的爆发。应用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术对172株腺病毒进行血清型分析，结果表明，腺病毒3型（Ad 3）占优势（87.2%），其次为Ad 2（6.4%）、Ad 1（4.1%）、Ad 7（1.2%）、Ad 4（0.6%）和Ad 5（0.6%）。采用限制性片段长度多态性分析（RFLP）方法对15株暴发期分离株的Ad 3基因进行了基因型分析。所有分离株均属于基因型Ad 3a 2。与基线期Ad 3感染者相比，暴发期Ad 3感染者中严重感染的比例显著增高（58.0%vs.40.2%，P=0.01），其中支气管肺炎（28.7%）、渗出性扁桃体炎（24.1%）和扁桃体炎（16.1%）的比例显著增高。此外，严重感染的患者明显比未感染的患者年轻（4.10 vs.8.15岁，P < 0.001）。总之，我们的研究表明，腺病毒3型是主要的血清型负责呼吸道腺病毒爆发在北方台湾在2004 - 2005年期间，并与严重感染的爆发期间。
An outbreak of respiratory adenovirus infection in children was observed in northern Taiwan between November 2004 and February 2005. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to determine the serotype(s) of 172 adenovirus isolates in the outbreak period, we found that adenovirus type 3 (Ad3) was the predominant type (87.2%), followed by Ad2 (6.4%), Ad1 (4.1%), Ad7 (1.2%), Ad4 (0.6%), and Ad5 (0.6%). The genotype of Ad3 was analyzed for 15 isolates from the outbreak period by RFLP of the full-length genome. All these isolates belonged to genotype Ad3a2. Compared with the Ad3-infected patients in the baseline period, a significantly higher proportion of Ad3-infected patients in the outbreak period had severe infections (58.0% vs. 40.2%, P=0.01), which included bronchopneumonia (28.7%), exudative tonsillitis (24.1%), and tonsillitis (16.1%). Moreover, patients with severe infections were significantly younger than those without (4.10 vs. 8.15 years, P < 0.001). In summary, our study demonstrated that Ad3 was the predominant serotype responsible for the respiratory adenovirus outbreak in northern Taiwan during 20042005 and was associated with severe infections in the outbreak period.