Increase of cardiolipin content in Staphylococcus aureus by the use of antibiotics affecting the cell wall.
Increase of cardiolipin content in Staphylococcus aureus by the use of antibiotics affecting the cell wall.
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通过使用影响细胞壁的抗生素来增加金黄色葡萄球菌中的心磷脂含量。
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
R. Kariyama
中科院分区：
文献类型：
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作者：
R. Kariyama
研究了影响金黄色葡萄球菌209 P细胞壁合成的抗生素对磷脂组成的影响。在中间指数生长期加入每种抗生素，并通过浊度法跟踪生长。青霉素、磷霉素、环丝氨酸、默诺霉素和头孢唑林引起浊度趋于平稳，并且生长停止而不裂解。恩拉霉素和杆菌肽是溶菌的。溶菌性抗生素引起的心磷脂含量的增加比那些非溶菌性抗生素。磷脂酰甘油的量与心磷脂含量的增加成比例地减少。由于溶菌抗生素结合十一肾上腺素，心磷脂的作用进行了讨论有关的细胞表面材料的合成机制。
Effect of antibiotics affecting cell wall synthesis on phospholipid composition in Staphylococcus aureus 209P was examined. Each antibiotic was added in the middle exponential growth phase and the growth was followed turbidimetrically. Penicillin, fosfomycin, cycloserine, moenomycin and cefazolin caused a leveling off of turbidity and growth to cease without lysis. Enramycin and bacitracin were bacteriolytic. Bacteriolytic antibiotics caused a greater increase of cardiolipin content than those that were non-bacteriolytic. The amount of phosphatidylglycerol decreased in proportion to the increment of cardiolipin content. Since bacteriolytic antibiotics bind to undecaprenol, the role of cardiolipin was discussed in relation to the mechanism of synthesis of cell surface materials.