BIAS DUE TO NONDIFFERENTIAL MISCLASSIFICATION OF POLYTOMOUS CONFOUNDERS
BIAS DUE TO NONDIFFERENTIAL MISCLASSIFICATION OF POLYTOMOUS CONFOUNDERS
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DOI：
10.1016/0895-4356(93)90009-p
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发表时间：
1993-01-01
影响因子：
7.2
通讯作者：
BRENNER, H
中科院分区：
文献类型：
--
作者：
BRENNER, H
本文讨论了多级混杂因素的非差异性错误分类对调整后的暴露-疾病关联的潜在影响。尽管混杂错误分类偏差的程度在很大程度上取决于比较暴露组之间混杂变量的相对分布和错误分类模式，但在大多数情况下，偏差与混杂的方向相同（尽管程度较小），即观察到的调整后的测量值位于粗略测量值和完全调整后的测量值之间。然而，在某些情况下，混杂因素错误分类偏差可能是相反的方向。这与之前的理解相反，之前的理解是非差异混杂因素错误分类总是倾向于使调整后的效应估计偏向粗略估计，并且这种偏差的程度与错误分类的程度具有稳定的关系。因此，关于任何给定研究中多级混杂因素的非差异性错误分类的潜在影响的结论只能在考虑错误分类率的合理范围的仔细敏感性分析之后得出。
This paper addresses potential effects of non-differential misclassification of Polytomous confounders on adjusted exposure-disease associations. Although the degree of confounder-misclassification bias heavily depends on the relative distribution of the confounding variable among the compared exposure groups and the misclassification pattern, in most cases the bias is in the same direction (though to a lesser degree) than the confounding, i.e. the observed adjusted measures lie between the crude and the fully adjusted measures. In some instances, however, the confounder misclassification bias may be in the opposite direction. This is in contrast to previous understanding that non-differential confounder misclassification always tends to bias adjusted effect estimates towards the crude estimates and that the extent of this bias has a stable relationship to the degree of misclassification. Consequently, conclusions on the potential effects of non-differential misclassification of a polytomous confounder in any given study should only be made after careful sensitivity analyses which consider plausible ranges of misclassification rates.