Differences in alveolar size in inbred mouse strains
Differences in alveolar size in inbred mouse strains
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DOI：
10.1016/j.resp.2004.02.003
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发表时间：
2004-06-25
影响因子：
2.3
通讯作者：
Mitzner, W
中科院分区：
文献类型：
--
作者：
Soutiere, SE;Tankersley, CG;Mitzner, W
在本文中，我们检查了结构差异的肺泡大小之间的近亲繁殖的小鼠菌株已知有显著差异的肺压力-体积关系。因此，我们评估了C3H/HeJ、C57BL/6J和A/J菌株中肺泡的相对大小或数量是否与这些肺容量差异有关。将这些菌株的肺固定在原位，然后切除进行空域弦长定量形态学分析。3株小鼠肺泡平均弦长差异有统计学意义（P < 0.0001）， C3H/HeJ小鼠肺泡最大（45 +/- 5），C57BL/6J小鼠肺泡最小（35 +/- 3），A/J小鼠肺泡居中（38 2）。这些发现提供了明确的证据，表明不同小鼠品系的肺结构存在显著的遗传差异。然而，由于A/J和C57BL/6J小鼠的肺体积相似，微观结构的宏观表现之间似乎还没有明确的联系。我们推测，这些结构差异可能对几种肺部疾病的小鼠模型产生重大影响，特别是那些涉及肺气肿发展的小鼠模型。(C) 2004 Elsevier B.V.版权所有
In this paper we examined structural differences in alveolar size among inbred Mouse strains which are known to have significant differences in lung pressure-volume relations. Accordingly, we assessed whether the relative size Or number of alveoli in the C3H/HeJ, C57BL/6J, and A/J strains are related to these lung Volume differences. Lungs from each of these strains were fixed in situ and then excised for quantitative morphometric analysis of airspace chord lengths. Mean chord lengths (in mum) were significantly different (P < 0.0001) among the three strains, with the largest alveoli found in the C3H/HeJ mice (45 +/- 5) the smallest in the C57BL/6J mice (35 +/- 3), and intermediate in the A/J strain (38 2). These findings provide clear evidence that there are sianificant genetic differences in the lung structure among different Mouse strains. However, since the A/J and C57BL/6J mice had similar lung volumes, there does not yet seem to be a clear link between the macroscopic manifestations of the microscopic structure. We speculate that these structural differences might have significant influence on several Mouse models of lung disease, especially those involving the development of emphysema. (C) 2004 Elsevier B.V. All rights reserved.