PROGNOSTIC ROLE OF EOSINOPHILS IN PULMONARY FIBROSIS
PROGNOSTIC ROLE OF EOSINOPHILS IN PULMONARY FIBROSIS
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DOI：
10.1378/chest.92.1.51
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发表时间：
1987-07-01
期刊：
影响因子：
9.6
通讯作者：
HUNNINGHAKE, GW
中科院分区：
文献类型：
--
作者：
PETERSON, MW;MONICK, M;HUNNINGHAKE, GW
特发性肺纤维化（IPF）和与胶原血管疾病相关的肺纤维化（PF-CVD）是慢性炎性肺病，其在不同亚组的患者中的特征可能是巨噬细胞、中性粒细胞、淋巴细胞和/或嗜酸性粒细胞数量增加。先前的研究表明，支气管肺泡灌洗（BAL）回收的细胞群可能在预测疾病进展和对治疗的反应方面很重要。我们在27例患者中评估了这一假设，通过确定在6个月的观察期内，BAL恢复的细胞群是否在肺功能改善、保持稳定或恶化（定义为用力肺活量至少变化15%）的患者之间存在差异。结果表明，BAL嗜酸性粒细胞可能是IPF和PF-CVD患者进行性肺部疾病的标志物。
Idiopathic pulmonary fibrosis (IPF) and pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD) are chronic inflammatory lung disorders which may be characterized in various subgroups of patients by increased numbers of macrophages, neutrophils, lymphocytes, and/or eosinophils. Previous studies have suggested that the cell populations recovered with bronchoalveolar lavage (BAL) may be important in predicting disease progression and response to therapy. We evaluated this hypothesis in 27 patients by determining if the cell populations recovered with BAL differed between patients who improved, remained stable, or worsened in their pulmonary functions (as defined by at least a 15 percent change in forced vital capacity) over a six-month observation period. The findings suggested that BAL eosionophila may be a marker of progressive lung disease in patients with IPF and PF-CVD.