Prevalence of inhaled antigen sensitization and nasal eosinophils in Japanese children under two years old
Prevalence of inhaled antigen sensitization and nasal eosinophils in Japanese children under two years old
复制标题
DOI：
10.1016/j.ijporl.2011.10.024
复制
发表时间：
2012-02-01
影响因子：
1.5
通讯作者：
Fujieda, Shigeharu
中科院分区：
文献类型：
--
作者：
Osawa, Yoko;Suzuki, Dai;Fujieda, Shigeharu
目的：变应性鼻炎（AR）的发病年龄越来越年轻，这已成为一个问题。本研究检测了2岁以下儿童吸入性抗原致敏和鼻嗜酸性粒细胞的患病率，测量了对屋尘螨、猫毛和日本雪松花粉的空气变应原特异性IgE抗体的血清浓度，测量了鼻嗜酸性粒细胞计数，并向儿童父母进行了问卷调查。方法：受试者是一组接受当地政府提供的18个月婴儿健康检查的健康儿童，以及儿科医院2岁以下的患病儿童。在408名健康婴儿中，44名（10.7%）有抗原特异性IgE抗体，29名（7.1%）有鼻嗜酸性粒细胞，8名（2.0%）有特异性IgE抗体和鼻嗜酸性粒细胞。鼻评估显示125名儿童有鼻漏。在对抗原和鼻嗜酸性粒细胞均表现出致敏的婴儿中，有6例（1.5%）确诊为鼻漏。在儿科医院的186名两岁以下的患病儿童中，有5名（2.6%）检测到空气过敏原特异性IgE抗体。鼻嗜酸性粒细胞的存在被证实在6名儿童（3.2%），这一百分比小于健康组。没有婴儿有致敏抗原或鼻嗜酸性粒细胞。结论：上述研究结果表明，AR的最低患病率可能是1.5%，在18个月大的儿童和约10%的受影响的儿童有空气过敏原特异性IgE抗体在日本。儿童AR的发病率可能会进一步增加。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Objective: The increasingly younger age of onset of allergic rhinitis (AR) has recently become a problem. This study examined the prevalence of inhaled antigen sensitization and nasal eosinophils in children younger than two years old, with measurement of the serum concentrations of aeroallergen-specific IgE antibodies to house dust mites, cat fur, and Japanese cedar pollen, measurement of nasal eosinophil counts, and a questionnaire administered to the children's parents.Methods: The subjects were a group of healthy children undergoing 18-month infant health checks provided by the local government, and sick children younger than two years old at the pediatric hospital.Results: Among 408 healthy infants, 44(10.7%) had antigen-specific IgE antibodies, 29 (7.1%) had nasal eosinophils, and eight (2.0%) had both specific IgE antibodies and nasal eosinophils. Nasal assessment revealed that 125 children had rhinorrhea. Of the infants who showed both sensitization to antigens and nasal eosinophils, six (1.5%) had confirmed rhinorrhea. Among 186 sick children younger than two years old at the pediatric hospital, aeroallergen-specific IgE antibodies were detected in five (2.6%). The presence of nasal eosinophils was confirmed in six children (3.2%), which percentage was smaller than that of the healthy group. No infant had either sensitization to antigens or nasal eosinophils.Conclusion: The findings described above indicate that the minimum prevalence of AR might be 1.5% in 18-month-old children and that around 10% of affected children have aeroallergen-specific IgE antibodies in Japan. The incidence of AR in young children might increase further. (C) 2011 Elsevier Ireland Ltd. All rights reserved.