Roles of reactive oxygen and nitrogen species in pain.
Roles of reactive oxygen and nitrogen species in pain.
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DOI：
10.1016/j.freeradbiomed.2011.01.026
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发表时间：
2011-09-01
影响因子：
7.4
通讯作者：
Neumann, William L.
中科院分区：
文献类型：
--
作者：
Salvemini, Daniela;Little, Joshua W.;Doyle, Timothy;Neumann, William L.
关键词：
Peroxynitrite (PN, ONOO−) and its reactive oxygen precursor superoxide (SO, O2·−), are critically important in the development of pain of several etiologies including in the development of pain associated with chronic use of opiates such as morphine (also known as opiate-induced hyperalgesia and antinociceptive tolerance). This is now an emerging field in which considerable progress has been made in terms of understanding the relative contribution of SO, PN, and nitroxidative stress in pain signaling at the molecular and biochemical levels. Aggressive research in this area is poised to provide the pharmacological basis for development of novel non-narcotic analgesics that are based upon the unique ability to selectively eliminate SO and/or PN. As we have a better understanding of the role of SO and PN in pathophysiological settings, targeting PN may be a better therapeutic strategy than targeting SO. This is due to the fact that unlike PN, which has no currently known beneficial role, SO may play a significant role in learning and memory. Thus, the best approach may be to spare SO while directly targeting its downstream product, PN. Over the last 15 years, our team has spearheaded research concerning the roles of SO/PN in pain and these results are currently leading to the development of solid therapeutic strategies in this important area.
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影响因子：
6.2
作者：
Bettoni, Isabella;Comelli, Francesca;Costa, Barbara
通讯作者：
Costa, Barbara
影响因子：
5.3
作者：
Abramov, AY;Canevari, L;Duchen, MR
通讯作者：
Duchen, MR
影响因子：
4.7
作者：
Amantini, C.;Mosca, M.;Santoni, G.
通讯作者：
Santoni, G.
DOI：
10.1073/pnas.92.16.7162
发表时间：
1995-08-01
影响因子：
11.1
作者：
BONFOCO, E;KRAINC, D;LIPTON, SA
通讯作者：
LIPTON, SA
影响因子：
5.5
作者：
Amadesi, Silvia;Cottrell, Graeme S.;Bunnett, Nigel W.
通讯作者：
Bunnett, Nigel W.