Synthesis of primary amines: First homogeneously catalyzed reductive amination with ammonia
Synthesis of primary amines: First homogeneously catalyzed reductive amination with ammonia
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DOI：
10.1021/ol0200605
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发表时间：
2002-06-13
期刊：
影响因子：
5.2
通讯作者：
Beller, M
中科院分区：
文献类型：
--
作者：
Gross, T;Seayad, AM;Beller, M
[图表]通过用氨水还原胺化相应的羰基化合物来合成伯胺，这是第一次用可溶性过渡金属络合物实现。在各种苯甲醛的情况下，使用铑催化剂与水溶性膦和乙酸铵一起使用，得到高达86%的收率和97%的苄胺选择性。在脂肪醛的情况下，基于Rh/Ir的双金属催化剂给出了改进的结果。
[GRAPHIC]The synthesis of primary amines via reductive amination of the corresponding carbonyl compounds with aqueous ammonia is achieved for the first time with soluble transition metal complexes. Up to an 86% yield and a 97% selectivity for benzylamines were obtained in the case of various benzaldehydes by using a Rh-catalyst together with water-soluble phosphine and ammonium acetate. In the case of aliphatic aldehydes, a bimetallic catalyst based on Rh/Ir gave improved results.