Neuronal responses in rabbit cingulate cortex linked to quick-phase eye movements during nystagmus.
Neuronal responses in rabbit cingulate cortex linked to quick-phase eye movements during nystagmus.
复制标题
兔子扣带皮层的神经元反应与眼球震颤期间的快速眼球运动有关。
DOI：
10.1152/jn.1988.59.3.922
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发表时间：
1988
影响因子：
2.5
通讯作者：
Swadlow,HA
中科院分区：
文献类型：
--
作者：
Sikes,RW;Vogt,BA;Swadlow,HA
1.观察了清醒家兔扣带回29区在前庭和视动性眼震时的反应。通过光学检测附着在角膜上的红外发光二极管的位置来测量眼球运动。2. 14%的扣带回细胞（477个孤立单位中的68个）的反应与快速阶段的发生相关。LaCl 4的范围从60毫秒前到220毫秒后的快速阶段的发病，平均70毫秒和58毫秒的标准差。大多数单位响应期间或快速阶段后，虽然四个单位的响应之前的快速阶段发病。3.快速阶段的单一反应不是由于视野移动，因为这些反应发生在黑暗中以及光明。这些反应不依赖于前庭刺激，因为在扣带快相神经元中观察到与自发性眼跳样眼球运动相关的反应。4.大多数（52个中的37个）快相神经元具有方向偏好。大约相同数量的定向单位响应于快速阶段，同侧和对侧相对于记录网站。5.大约四分之一的快速相位单位是双向的（52个中的15个），对同侧和对侧快速相位的反应几乎相等。6.听觉和/或体感反应中观察到的快速相细胞只有五个。所有这些多式联运单位都是双向的。7.组织学证实快相单位主要位于扣带回皮质29 d区。虽然大多数细胞位于第V层，但有些细胞被隔离在第II-III层中。8.扣带皮层与视皮层和与动眼神经相关的丘脑核团有相互联系，并投射到参与眼球控制的上级丘层。扣带神经元对快速相位的反应可能会使扣带皮层的反应与新的、潜在的重要视觉信息的到来同步。
1. Responses of single units in area 29 of cingulate cortex were examined in alert rabbits during vestibular and optokinetic nystagmus. Eye movements were measured by optically detecting the position of an infrared light-emitting diode attached to the cornea. 2. Fourteen percent of cingulate cells (68 of 477 isolated units) had responses that were correlated to the occurrence of quick phases. Latencies ranged from 60 ms before to 220 ms after the onset of the quick phase with a mean of 70 ms and standard deviation of 58 ms. Most units responded during or following quick phases, although four units had responses that preceded the quick-phase onset. 3. Unitary responses during quick phases were not due to visual field movement, since these responses occurred in the dark as well as the light. The responses were not dependent upon vestibular stimulation, since responses related to spontaneous saccadelike eye movements were observed in cingulate quick-phase neurons. 4. The majority (37 of 52) of the quick-phase neurons had a directional preference. Approximately equal numbers of directional units responded to quick phases directed ipsilaterally and contralaterally with respect to the recording site. 5. About one-fourth of the quick-phase units were bidirectional (15 of 52) with virtually equal responses to ipsilaterally and contralaterally directed quick phases. 6. Auditory and/or somatosensory responses were observed in only five of the quick-phase cells. All such multimodal units were bidirectional. 7. The quick-phase units were histologically confirmed to be primarily in area 29d of cingulate cortex. Although most cells were located in layer V, some were isolated in layer II-III. 8. Cingulate cortex has reciprocal connections with visual cortex and oculomotor-related thalamic nuclei and projects to the layers of the superior colliculus that are involved in oculomotor control. Responses to quick phases in cingulate neurons may synchronize cingulate cortex responsiveness with the arrival of new, and potentially significant, visual information.