New polychlorinated pyrrolidinones from the Red Sea marine sponge Lamellodysidea herbacea
New polychlorinated pyrrolidinones from the Red Sea marine sponge Lamellodysidea herbacea
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DOI：
10.1016/j.tet.2004.11.011
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发表时间：
2005-01-24
期刊：
影响因子：
2.1
通讯作者：
Bourguet-Kondracki, ML
中科院分区：
文献类型：
--
作者：
Sauleau, P;Retailleau, P;Bourguet-Kondracki, ML
对红海海洋海绵Lamellodysidea herbacea的二氯甲烷提取物的化学研究导致除了已知的dysidamide 1、dysidamide B2和dysidamide C7之外还分离出7种新的多氯化衍生物3-6和8-10。通过大量的NMR光谱数据确定了它们的结构。化合物9的绝对构型由X-射线晶体衍射分析确定。在0.8 μ g/ml时，Dysidamide 1对中脑和皮质鼠神经元均表现出神经毒性作用。(C)2004爱思唯尔有限公司保留所有权利。
Chemical investigation of the dichloromethane extract of the Red Sea marine sponge Lamellodysidea herbacea led to the isolation of seven new polychlorinated derivatives 3-6 and 8-10 in addition to the known dysidamide 1, dysidamide B2 and dysidamide C7. Their structures were established by extensive NMR spectroscopic data. The absolute configuration of compound 9 was determined by X-ray crystallographic diffraction analysis. Dysidamide 1 exhibited neurotoxic effects towards both mesencephalic and cortical murine neurones at 0.8 mug/ml. (C) 2004 Elsevier Ltd. All rights reserved.