PEG-based surface modification on upconversion nanophosphors for bio-imaging under IR excitation
PEG-based surface modification on upconversion nanophosphors for bio-imaging under IR excitation
复制标题
DOI：
10.2494/photopolymer.19.145
复制
发表时间：
2006-01-01
影响因子：
0.8
通讯作者：
Nagasaki, Yukio
中科院分区：
文献类型：
--
作者：
Konishi, Tomoya;Yamada, Masayoshi;Nagasaki, Yukio
荧光生物成像中最严重的问题之一是荧光探针的褪色和对生物系统的损伤对观察时间的限制，而这两者都是由激发紫外线照射引起的。利用红外激发下稀土掺杂无机纳米荧光粉的上转换发射可以解决这一问题。纳米荧光粉作为生物成像探针的应用，需要通过生物相容性聚合物对其表面进行修饰，才能在有机组织中获得生物功能。在本文中，作者证明了聚丙烯酸（PAAc）和α -缩醛-聚乙二醇-嵌段-[聚（2-（N，N-二甲氨基）甲基丙烯酸乙酯）]作为上转化纳米荧光粉在掺铒的Y2O3纳米颗粒上的形成。利用zeta电滴定法和红外振动光谱测量证实了这些层的存在。
One of the most serious problems in fluorescence bio-imaging is the limitation of observation time due to color-fading of the fluorescence probes and damages on the bio system, both of which are caused by the excitation ultraviolet irradiation. This problem can be solved by using an upconversion emission of rare-earth doped inorganic nanophosphors under infrared excitation. For the application of nanophosphors as bio-imaging probes, surface modification by biocompatible polymers is needed to obtain biological functionality in organic tissues. In this paper, authors demonstrate the formation of poly(acrylic acid) (PAAc) and alpha-acetal-poly (ethylene glycol)-block-[poly (2-(N,N-dimethylamino) ethyl methacrylate)] multilavers on the Er-doped Y2O3 nanoparticles as an upconversion nanophosphor. The existence of the layers was confirmed by using zeta electrometry and infrared vibrational spectroscopy measurements.