Chromosome territories -: a functional nuclear landscape
Chromosome territories -: a functional nuclear landscape
复制标题
DOI：
10.1016/j.ceb.2006.04.007
复制
发表时间：
2006-06-01
影响因子：
7.5
通讯作者：
Fakan, Stanislav
中科院分区：
文献类型：
--
作者：
Cremer, Thomas;Cremer, Marion;Fakan, Stanislav
了解细胞核的结构对于了解细胞类型依赖的活性和沉默基因的编排以及其他核功能（如RNA剪接，DNA复制和修复）是必不可少的。然而，虽然现在普遍认为细胞核中的染色体被组织为染色体领土，但目前的染色体领土结构模型在细胞周期和终末细胞分化期间这种结构的动态变化的可能功能影响方面存在很大差异。
Understanding nuclear architecture is indispensable for understanding the cell-type-dependent orchestration of active and silent genes and other nuclear functions, such as RNA splicing, DNA replication and repair. Yet, while it is now generally agreed that chromosomes in the cell nucleus are organized as chromosome territories, present models of chromosome territory architecture differ widely with respect to the possible functional implications of dynamic changes of this architecture during the cell cycle and terminal cell differentiation.