Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark
Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark
复制标题
DOI：
10.1016/j.phymed.2009.05.016
复制
发表时间：
2010-02-01
期刊：
影响因子：
7.9
通讯作者：
Shinde, D. B.
中科院分区：
文献类型：
--
作者：
Chavan, M. J.;Wakte, P. S.;Shinde, D. B.
从番荔枝树皮的未皂化石油醚提取物中分离出环氧卡环烯，并对其镇痛和抗炎活性进行了研究。在12.5和25 mg/kg体重剂量下，和剂量为50 mg/kg体重的未皂化石油醚提取物。显示出显著的中枢和外周镇痛，沿着抗炎活性。氧化卡勒烯的这些活性与相应实验中使用的标准药物相当。(C)2009年Elsevier GmbH。All rights reserved.
Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity. Caryophyllene oxide at the doses of 12.5 and 25 mg/kg body wt. and unsaponified petroleum ether extract at a dose of 50 mg/kg body wt. showed significant central as well as peripheral analgesic, along with anti-inflammatory, activity. These activities of caryophyllene oxide were comparable with the standard drug used in the respective experiments. (C) 2009 Elsevier GmbH. All rights reserved.