Visible‐Light‐Mediated C(sp 3 )–H Thiocarbonylation for Thiolactam Preparation with Potassium Sulfide
Visible‐Light‐Mediated C(sp 3 )–H Thiocarbonylation for Thiolactam Preparation with Potassium Sulfide
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DOI：
10.1002/cjoc.201900360
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发表时间：
2019-12
影响因子：
5.4
通讯作者：
W. Tan;Cui-Hong Wang;Xuefeng Jiang
中科院分区：
文献类型：
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作者：
W. Tan;Cui-Hong Wang;Xuefeng Jiang
本文报道了一种可见光介导的C(sp3) -H硫代羰基化法制备硫内酰胺的方案，其中硫化钾生成的多硫离子和自由基阴离子是关键活性物质。在温和条件下，直接建立了多种硫内酰胺。并成功应用于四氢小檗碱的结构修饰。
Summary of main observation and conclusionWe report herein a protocol for thiolactam preparation with potassium sulfide via visible‐light‐mediated C(sp3)–H thiocarbonylation, in which polysulfide dianions and radical anions generated from potassium sulfide were the key active species. A variety of thiolactams were straightforward established under mild conditions. Moreover, it was successfully applied to structural modification of tetrahydroberberine.