Retinal phenotyping of variants of Alzheimer's disease using ultra-widefield retinal images.
Retinal phenotyping of variants of Alzheimer's disease using ultra-widefield retinal images.
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DOI：
10.1002/dad2.12232
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Lengyel I
中科院分区：
文献类型：
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作者：
Csincsik L;Quinn N;Yong KXX;Crutch SJ;Peto T;Lengyel I
后皮质萎缩（PCA）是阿尔茨海默病（AD）最常见的非典型变体。与PCA相关的大脑变化影响视觉皮层，但对PCA的视网膜变化知之甚少。在这项研究中，我们探讨了典型AD （tAD）和PCA的视网膜表型变化。对69名对照组、24名tAD和25名PCA参与者的超宽视场（UWF）图像进行视网膜表型分析。tAD（比值比[OR] = 2.76[置信区间（CI）：1.24 ~ 6.10], P = 0.012）和PCA （OR = 3.40 [CI:1.25 ~ 9.22], P = 0.016）的个体更有可能表现为重度吸毒者。与对照组相比，tAD （OR = 0.34 [CI:0.12 ~ 0.92], P = 0.035）发生软性醉酒的可能性较低。据估计，与对照组相比，tAD中网状伪结节的形成增加了近3倍（OR = 2.93 [CI:1.10至7.76],P = 0.030）。研究周围视网膜可能有助于更好地理解不同AD变体视网膜表型的差异。使用超宽视场视网膜图像研究阿尔茨海默病变体视网膜表型的工作流程。
Posterior cortical atrophy (PCA) is the most common atypical variant of Alzheimer's disease (AD). Changes associated with PCA in the brain affect the visual cortex, but little is known about retinal changes in PCA. In this study, we explored retinal phenotypic variations in typical AD (tAD) and PCA. Retinal phenotyping was carried out on ultra‐widefield (UWF) images of 69 control, 24 tAD, and 25 PCA participants. Individuals with tAD (odds ratio [OR] = 2.76 [confidence interval (CI):1.24 to 6.10], P = .012) and PCA (OR = 3.40 [CI:1.25 to 9.22], P = .016) were more likely phenotyped as hard drusen. tAD (OR = 0.34 [CI:0.12 to 0.92], P = .035) were less likely to have soft drusen compared to control. Almost 3‐fold increase in reticular pseudodrusen formation in tAD (OR = 2.93 [CI:1.10 to 7.76], P = .030) compared to control was estimated. Studying the peripheral retina may contribute to a better understanding of differences in retinal phenotypes of different AD variants. Workflow for the Retinal phenotyping of variants of Alzheimer's disease using ultra widefield retinal images study.