Pilot evaluation of gabapentin for treating hot flashes
Pilot evaluation of gabapentin for treating hot flashes
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DOI：
10.4065/77.11.1159
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发表时间：
2002-11-01
影响因子：
8.9
通讯作者：
Christensen, BJ
中科院分区：
文献类型：
--
作者：
Loprinzi, CL;Barton, DL;Christensen, BJ
目的：获得关于加巴喷丁缓解潮热的功效和耐受性的初步前瞻性数据。患者和方法：这项前瞻性单臂临床试验于 2001 年 7 月 26 日至 2001 年 7 月 26 日进行。 2001 年 11 月 30 日。患者接受一周基线治疗，然后接受 4 周加巴喷丁治疗，前 3 周剂量逐渐增加，从 300 毫克/天增加到 600 毫克/天，再到 900 毫克/天。数据主要来自患者填写的问卷。结果：可获得来自 20 名可评估女性（参与试验的 24 名女性）的数据。四名患者因感知到与药物相关的不良症状（主要与头晕和头晕有关）而停止使用加巴喷丁。与基线周相比，完成本临床试验的 16 名患者在治疗第四周的潮热频率平均降低了 66%。他们相应的潮热评分（频率乘以平均严重程度）降低了 70%。此外，完成的患者。 4 治疗周有强烈报告其他几种症状有所改善的趋势。结论：虽然是双盲安慰剂对照临床试验，但仍应进行更好的阐明。关于加巴喷丁对潮热患者的疗效和毒性，现有数据表明，如果潮热患者不想使用激素治疗，加巴喷丁是一种合理的治疗方法。
Objective: To obtain pilot prospective data regarding the efficacy and tolerability of gabapentin for alleviating, hot flashes.Patients and Methods: This prospective single-arm clinical trial was conducted between July 26, 2001, and,. November 30, 2001. Patients underwent a baseline week and then 4 weeks of gabapentin treatment, with increasing, doses during the first 3 weeks, from 300 to 600 to 900 mg/d. Data were obtained primarily from patient-completed questionnaires.Results: Data from 20 evaluable women (of 24 entered in the trial) were available. Four patients discontinued use of gabapentin for perceived drug-related untoward symptoms, primarily related to light-headedness and dizziness. The 16 patients who completed this clinical trial had a mean reduction in hot flash frequency, in the fourth treatment week compared to the baseline week, of 66%. Their corresponding hot flash score (frequency times average severity) reduction was 70%. Additionally, patients who completed. the 4 treatment weeks had a strong tendency to report an improvement in several other symptoms.Conclusion: Although a double-blind placebo-controlled clinical trial, should be conducted to better elucidate. the-efficacy and toxicity of gabapentin in patients with hot flashes, the available data suggest that gabapentin is a reasonable treatment to consider in patients with hot flashes if they do not wish to use hormonal therapy.