Reduced expression of Raf-1 kinase inhibitory protein predicts regional lymph node metastasis and shorter survival in esophageal squamous cell carcinoma
Reduced expression of Raf-1 kinase inhibitory protein predicts regional lymph node metastasis and shorter survival in esophageal squamous cell carcinoma
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DOI：
10.1016/j.prp.2012.02.011
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Kim, Youn Wha
中科院分区：
文献类型：
--
作者：
Kim, Hyun-Soo;Won, Kyu Yeoun;Kim, Youn Wha
RAF-1激酶抑制蛋白(RKIP)是一种转移抑制因子，与人类恶性肿瘤的进展和转移呈负相关。本研究评价了RKIP在食管鳞癌中的表达与转移潜能、临床病理特征和患者预后的关系。我们检测了138例胸腔鳞状细胞癌患者的组织标本。应用免疫组织化学方法检测RKIP在原位鳞癌、原发鳞癌和转移性鳞癌中的表达。RKIP在原位鳞癌、原发和转移性鳞癌中的表达分别为28.9%(13/45)、50.0%(69/138)和71.4%(65/91)。这些水平的RKIP下调明显不同。RKIP的表达与组织学分级(P=0.008)、病理T分期(P=0.044)、淋巴侵犯(P=0.019)、区域淋巴结转移(P=0.002)和分期(P=0.041)呈负相关。病理T分期(P=0.001)、淋巴侵犯(P<；0.001)和RKIP表达降低(P=0.039)是食管癌局部淋巴结转移的独立预测因素。此外，RKIP表达减少的食管鳞癌患者的术后生存期明显短于RKIP表达阳性的食管鳞癌患者(P=0.004)。食管鳞癌组织中RKIP表达降低与疾病进展、局部淋巴结转移及预后不良有关。RKIP的表达可作为ESCC患者的一种新的临床生物标志物。(C)2012年爱思唯尔股份有限公司。版权所有。
Raf-1 kinase inhibitory protein (RKIP), a suppressor of metastasis, is associated inversely with the progression and metastasis of human malignancies. The present study evaluated relationships between RKIP expression and metastatic potential, clinicopathological characteristics and patient outcome in esophageal squamous cell carcinoma (ESCC). We examined tissue specimens from 138 patients with thoracic ESCC. Using immunohistochemistry, RKIP expression was detected in ESCC in situ, primary ESCC and nodal metastatic ESCC. RKIP expression was reduced in 28.9% (13/45) of ESCC in situ, in 50.0% (69/138) of primary ESCC and in 71.4% (65/91) of nodal metastatic ESCC. These levels of RKIP down-regulation differed significantly. RKIP expression was associated inversely with histological grade (P = 0.008), pathological T stage (P = 0.044), lymphatic invasion (P = 0.019), regional lymph node metastasis (LNM; P = 0.002) and stage (P = 0.041). Pathological T stage (P = 0.001), lymphatic invasion (P < 0.001) and reduced RKIP expression (P = 0.039) were independent predictors of regional LNM in ESCC. In addition, the postoperative survival of patients with RKIP-reduced ESCC was significantly shorter than for patients with RKIP-positive ESCC (P = 0.004). Reduced RKIP expression in ESCC correlated with advanced disease, regional LNM and poor prognosis. RKIP expression may serve as a novel clinical biomarker in patients with ESCC. (C) 2012 Elsevier GmbH. All rights reserved.