Age-dependent changes in noradrenergic innervations of the frontal cortex in F344 rats
Age-dependent changes in noradrenergic innervations of the frontal cortex in F344 rats
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DOI：
10.1016/s0197-4580(00)00203-7
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发表时间：
2001-03-01
影响因子：
4.2
通讯作者：
Isobe, K
中科院分区：
文献类型：
--
作者：
Ishida, Y;Shirokawa, T;Isobe, K
采用免疫组织化学方法，定量观察F344雄性大鼠年龄（9、13、25月龄）额叶皮层去甲肾上腺素能神经分布，测定其多巴胺-对羟化酶（DBH）水平。在额叶皮层测量dbh阳性轴突的密度、静脉曲张（沿释放去甲肾上腺素的轴突的肿胀）和每单位长度轴突的静脉曲张数。我们发现，轴突密度和静脉曲张在衰老早期（9-13个月）明显下降，但在衰老后期（13-25个月）没有明显下降。另一方面，每单位长度轴突的变异数不随年龄变化。结果表明，在衰老早期，大脑额叶皮层中代表去甲肾上腺素能神经元突触的曲张密度下降。(C) 2001爱思唯尔科学公司版权所有。
Noradrenergic innervations of the frontal cortex with advancing age (9, 13 and 25 months) in male F344 rats were quantified by immunohistochemistry for dopamine-P-hydroxylase (DBH), which is a marker enzyme for noradrenergic axons. The density of DBH-positive axons, varicosities (swellings along an axon from which noradrenaline is released), and the number of varicosities per unit length of axon were measured in the frontal cortex. We found that the density of axons and varicosities significantly decreased at an earlier stage of aging (9-13 months), but not at a later stage (13-25 months). On the other hand, the number of varicosities per unit length of axon did not change with age. The result shows that the density of varicosities, which represent the synapses of noradrenergic neurons, decrease in the frontal cortex in the early aging process. (C) 2001 Elsevier Science Inc. All rights reserved.