Cardiovascular Consequences of Obesity and Targets for Treatment.

Cardiovascular Consequences of Obesity and Targets for Treatment.
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DOI:
10.1016/j.ddstr.2008.07.001
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发表时间:
2008-01-01
期刊:
Drug discovery today. Therapeutic strategies
影响因子:
--
通讯作者:
Peterson, Linda R
Peterson, Linda R
中科院分区:
其他
文献类型:
--
作者:
Mittendorfer, Bettina;Peterson, Linda R

文献摘要

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肥胖是心血管疾病的危险因素,包括冠状动脉疾病和心力衰竭,但它可能导致这些疾病的机制尚不完全清楚。目前,针对肥胖相关心血管疾病的治疗包括减肥策略和减少与肥胖和心血管疾病相关的其他风险因素。其他途径与潜在的药物开发肥胖相关的心血管疾病也进行了讨论。
Obesity is a risk factor for cardiovascular disease, including coronary artery disease and heart failure, but the mechanisms by which it may cause them are not completely clear. Currently, therapies aimed at obesity-related cardiovascular disease include weight loss strategies and reduction of the other risk factors that are associated with obesity and cardiovascular disease. Other pathways with for potential drug development for obesity-related CVD are also discussed.