KAINIC ACID INDUCES EARLY AND DELAYED DEGENERATIVE NEURONAL CHANGES IN RAT SPINAL-CORD
KAINIC ACID INDUCES EARLY AND DELAYED DEGENERATIVE NEURONAL CHANGES IN RAT SPINAL-CORD
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DOI：
10.1016/0304-3940(89)90585-5
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发表时间：
1989-10-09
影响因子：
2.5
通讯作者：
BARTHE, D
中科院分区：
文献类型：
--
作者：
HUGON, J;VALLAT, JM;BARTHE, D
在大鼠中进行海人酸和氯化钠的鞘内注射以研究在脊髓中观察到的细胞修饰。早期神经元的变化（2和24小时）相关的黑暗和萎缩或肿胀和空泡化的细胞。迟发性（3、6、14天）变化主要表现为运动神经元退行性变，核偏心和凹陷，细胞肿胀，近端神经突扩大，出现脂褐素样色素，胞浆内细胞器紊乱和细丝堆积。
Intrathecal injections of kainic acid and sodium chloride were performed in rats to study the cellular modifications observed in spinal cord. Early neuronal changes (2 and 24 h) associated dark and shrunken or swollen and vacuolated cytoplasms. Delayed (3, 6, 14 days) changes, mainly consisted in degenerative aspect of motoneurons with eccentric and indented nucleus, swollen cytoplasms with proximal neurite enlargements, the presence of ''lipofuscin-like'' pigments, disorganized intracytoplasmic organelles and filament accumulations.