Short term study of sucrose polyester a nonabsorbable fat-like material as a dietary agent for lowering plasma cholesterol.
Short term study of sucrose polyester a nonabsorbable fat-like material as a dietary agent for lowering plasma cholesterol.
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蔗糖聚酯（一种不可吸收的脂肪类材料）作为降低血浆胆固醇的饮食剂的短期研究。
DOI：
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发表时间：
1976
影响因子：
7.1
通讯作者：
F. Mattson
中科院分区：
文献类型：
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作者：
R. Fallat;C. Glueck;R. Lutmer;F. Mattson
蔗糖聚酯(SPE)是一种脂肪样物质，既不被消化也不被吸收，它的有效性、安全性和可接受性在13名正常受试者和7名高胆固醇血症受试者中进行了评估，以确定其作为降胆固醇药物的潜力。在正常胆固醇血症患者的饮食中添加或替代膳食脂肪，总胆固醇和低密度脂蛋白胆固醇的平均降幅分别为14%和17%(P<0.001)，尽管每天摄入含有800毫克胆固醇和脂肪的饮食，P/S比率为0.4%。在7名有家族性高胆固醇血症的受试者中，类似的10天SPE喂养期并没有显著降低总胆固醇和低密度脂蛋白胆固醇。接受SPE治疗的正常或高胆固醇血症患者的高密度脂蛋白胆固醇和甘油三酯没有改变。服用SPE的正常和高胆固醇血症患者的血浆维生素A和E水平分别下降了10%和21%(P<0.001和P<0.02)。当停止消费SPE时，这些指标恢复到基本水平。SPE在粪便中定量恢复(大于97%)，最后一次可测量的SPE是在停止摄入SPE后第3至5天发现的。尽管在喂养SPE的过程中，粪便中恢复了50g或更多的未水解性SPE，但没有出现临床或化学脂肪泻。在减去SPE对粪便总脂肪酸的摄入量后，发现在喂食SPE的过程中，粪便中的“非SPE”脂肪酸并没有增加，SPE很容易被添加到常规食物中，或者取代传统的饮食脂肪。根据这种对人类的短期评估和对老鼠和狗的其他调查。SPE似乎具有作为降胆固醇药物的潜力。
The efficacy, safety, and acceptability of sucrose polyester (SPE), a fat-like material that is neither digested nor absorbed, were assessed in 13 normal and seven hypercholesterolemic subjects for its potential as a cholesterol-lowering agent. Addition or substitution of SPE for culinary fats in the diets of the normocholesterolemic individuals produced a mean reduction of total and low-density lipoprotein cholesterol of 14 and 17%, respectively (P less than 0.001), despite the daily ingestion of a diet containing 800 mg of cholesterol and of dietary fat with a P/S ratio of 0.4. Total and low-density lipoprotein cholesterol were not significantly reduced by similar 10-day feeding periods of SPE in seven subjects with familial hypercholesterolemia. High-density lipoprotein cholesterol and triglycerides were not changed in normal or hypercholesterolemic subject receiving SPE. Plasma vitamin A and E levels were reduced by 10 and 21% (p less than 0.02 and less than 0.001) in both normal and hypercholesterolemic subjects on SPE. These returned to the basal levels when SPE consumption was discontinued. SPE was recovered quantitatively (greater than 97%) in the stools, with the last measurable SPE being found day 3 to 5 after cessation of SPE intake. Despite recovery of 50 g or more of unhydrolyzed SPE in stools during SPE feeding, there was no clinical or chemical steatorrhea. On subtracting SPE's input to total stool fatty acids, it was found that "non-SPE" fatty acids in the stool had not increased during SPE feeding, SPE was easily incorporated into routine foodstuffs in addition to, or in substitution for, conventional dietary fats. On the basis of this short term evaluation in humans and other investigations with the rat and dog. SPE appears to have potential as a cholesterol-lowering agent.