Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy
Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy
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DOI：
10.1039/b921114b
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发表时间：
2010-01-01
期刊：
影响因子：
3.1
通讯作者：
Burley, Jonathan
中科院分区：
文献类型：
--
作者：
Al-Dulaimi, Sarah;Aina, Adeyinka;Burley, Jonathan
我们证明了使用原位声子模式拉曼光谱可以快速实现对毫克量材料的药物化合物多态性筛选，并表明声子模式拉曼光谱（10-400 cm(-1)）可以用作“多态性指纹”。
We demonstrate that screening of pharmaceutical compounds for polymorphism can be rapidly achieved for milligram quantities of material using in situ phonon-mode Raman spectroscopy, and suggest that phonon-mode Raman spectra (10-400 cm(-1))can be used as "polymorphic fingerprints''.