Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk.
Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk.
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DOI：
10.1038/sj.bjc.6605074
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发表时间：
2009-06-02
影响因子：
8.8
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中科院分区：
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高加索妇女的乳腺癌发病率和出生体重高于亚洲妇女，出生体重与乳腺癌风险呈正相关。然而，白种人的妊娠激素水平普遍低于亚洲妇女。我们研究了1994-1995年在美国波士顿出生的92名单胎婴儿和在中国上海出生的110名单胎婴儿的脐带血中胰岛素样生长因子（IGF）系统的组分。高加索人的脐带血IGF-1显著高于中国婴儿（P<10−6）。而IGF-2则相反（P <0.010 −4）。IGF-1与波士顿的出生体重和出生身长呈显著正相关，而与上海的出生体重和出生身长无显著相关。与此相反，更强的积极，虽然统计学上不显着，IGF-2与出生大小的关联只在上海明显。出生体重和出生身长的相关性在较高的女性中是积极的和显著的（波士顿的IGF-1分别为P <0.003和0.03;上海的IGF-2分别为P <0.05和0.04），其中母亲的人体测量对胎儿生长没有很强的限制。较高的脐带血IGF-1水平的文件，一个主要的生长激素，不穿过胎盘，在高加索人比亚洲新生儿是一致的乳腺癌发病率在这些人群。
Breast cancer incidence and birth weight are higher among Caucasian than Asian women, and birth size has been positively associated with breast cancer risk. Pregnancy hormone levels, however, have been generally lower in Caucasian than Asian women. We studied components of the insulin-like growth factor (IGF) system in cord blood from 92 singleton babies born in Boston, USA, and 110 born in Shanghai, China, in 1994–1995. Cord blood IGF-1 was significantly higher among Caucasian compared with Chinese babies (P<10−6). The opposite was noted for IGF-2 (P∼10−4). IGF-1 was significantly positively associated with birth weight and birth length in Boston, but not Shanghai. In contrast, stronger positive, though statistically non-significant, associations of IGF-2 with birth size were only evident in Shanghai. The associations of birth weight and birth length were positive and significant in taller women (for IGF-1 in Boston P∼0.003 and 0.03, respectively; for IGF-2 in Shanghai P∼0.05 and ∼0.04, respectively), among whom maternal anthropometry does not exercise strong constraints in foetal growth. The documentation of higher cord blood levels of IGF-1, a principal growth hormone that does not cross the placenta, among Caucasian than in Asian newborns is concordant with breast cancer incidence in these populations.