CD40 ligand-CD40 interaction in Ig isotype switching in mature and immature human B cells.
CD40 ligand-CD40 interaction in Ig isotype switching in mature and immature human B cells.
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DOI：
10.1006/smim.1994.1038
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发表时间：
1994-10-01
影响因子：
7.8
通讯作者：
de Vries, J E
中科院分区：
文献类型：
--
作者：
Aversa, G;Punnonen, J;de Vries, J E
CD 40配体（CD 40 L）是TNF家族的成员，并且已经成为B细胞活化和分化所需的接触介导信号中的关键分子。在异源细胞上表达或以可溶性多聚体分子形式表达的克隆的CD 40 L可以直接激活B细胞，并且与细胞因子结合可以诱导幼稚B细胞中的IG同种型转换。由于CD 40 L表达缺陷而导致的高IgM综合征患者，除了IgM外，通常没有循环IG，表明CD 40 L在体内对于IG同种型转换也很重要。CD 40 L在B细胞发育中不起作用，并且似乎不是人类活化和分化所需的。CD 40 L在T细胞以外的细胞上的存在、其配体CD 40的相对广泛的分布以及T细胞通过CD 40 L共刺激的能力表明CD 40 L-CD 40介导的细胞间通讯具有更广泛的作用。
The CD40 ligand (CD40L) is a member of the TNF family, and has emerged as a key molecule in the contact-mediated signal required for B cell activation and differentiation. The cloned CD40L expressed on heterologous cells, or in the form of soluble multimeric molecules, can directly activate B cells and, in conjunction with cytokines, can induce Ig isotype switching in naive B cells. Patients with hyper-IgM syndrome, which results from defective CD40L expression, generally have no circulating Ig, except for IgM, indicating that the CD40L is also important for Ig isotype switching, in vivo. CD40L does not play a role in B cell development and appears not to be required for human activation and differentiation. The presence of CD40L on cells other than T cells, the relatively broad distribution of its ligand CD40, and the ability of T cells to be co-stimulated via CD40L, indicates a broader role for CD40L-CD40 mediated intercellular communication.