Magnetic resonance elastography-derived stiffness of the kidneys and its correlation with water perfusion
Magnetic resonance elastography-derived stiffness of the kidneys and its correlation with water perfusion
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DOI：
10.1002/nbm.4237
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发表时间：
2019-12-30
影响因子：
2.9
通讯作者：
Kolipaka, Arunark
中科院分区：
文献类型：
--
作者：
Gandhi, Deep;Kalra, Prateek;Kolipaka, Arunark
僵硬在诊断肾纤维化中起着重要作用。然而，在许多肾脏疾病中，肾脏的僵硬会因血流灌注的变化而改变。因此，本研究的目的是确定肾脏僵硬与水摄入量之间的相关性。我们假设，摄入1 L的水会增加肾脏的硬度，这是因为肾脏的水灌注量增加。此外，肾脏的硬度将与摄水前后的表观扩散系数(ADC)和分数各向异性(FA)值相关。对24例健康受试者(年龄22~66岁)在摄水1L前、后进行磁共振弹性成像和弥散张量成像，并在摄水前、后行3DT1加权膀胱扫描，测量膀胱体积。除了膀胱容量外，还进行了配对t检验以评估摄入水对肾脏硬度的影响。采用Spearman相关检验，确定两个肾脏在摄水前后的硬度、膀胱体积、ADC值和FA值之间的相关性。结果显示，摄水后肾脏不同区域的硬度显著增加(百分比增加3.6%至7.5%)，膀胱容量显著增加(均P<；0.05)。肾硬度变化与膀胱体积呈中度显著负相关(一致性相关系数=-0.468，P<0.05)。摄入水分前后，肾脏硬度与ADC值和FA值之间无显著相关性(P>；0.05)。摄入水会显著增加肾脏的僵硬程度。摄水前后肾脏硬度和膀胱体积的变化呈负相关，表明肾脏的灌流压力较高，导致硬度增加。
Stiffness plays an important role in diagnosing renal fibrosis. However, kidney stiffness is altered by perfusion changes in many kidney diseases. Therefore, the aim of the current study is to determine the correlation of kidney stiffness with water intake. We hypothesize that kidney stiffness will increase with 1 L of water intake due to increased water perfusion to the kidneys. Additionally, stiffness of the kidneys will correlate with apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values before and after water intake. A 3 T MRI scanner was used to perform magnetic resonance elastography and diffusion tensor imaging of the kidneys on 24 healthy subjects (age range: 22-66 years) before and after water intake of 1 L. A 3D T1-weighted bladder scan was also performed to measure bladder volume before and after water intake. A paired t-test was performed to evaluate the effect of water intake on the stiffness of kidneys, in addition to bladder volume. A Spearman correlation test was performed to determine the association between stiffness, bladder volume, ADC and FA values of both kidneys before and after water intake. The results show a significant increase in stiffness in different regions of the kidney (ie, percentage increase ranged from 3.6% to 7.5%) and bladder volume after water intake (all P < 0.05). A moderate significant negative correlation was observed between change in kidney stiffness and bladder volume (concordance correlation coefficient = -0.468, P < 0.05). No significant correlation was observed between stiffness and ADC or FA values before and after water intake in both kidneys (P > 0.05). Water intake caused a significant increase in the stiffness of the kidneys. The negative correlation between the change in kidney stiffness and bladder volume, before and after water intake, indicates higher perfusion pressure in the kidneys, leading to increased stiffness.