Circulating Very Long-Chain Saturated Fatty Acids and Heart Failure: The Cardiovascular Health Study
Circulating Very Long-Chain Saturated Fatty Acids and Heart Failure: The Cardiovascular Health Study
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DOI：
10.1161/jaha.118.010019
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发表时间：
2018-11-06
影响因子：
5.4
通讯作者：
Mozaffarian, Dariush
中科院分区：
文献类型：
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作者：
Lemaitre, Rozenn N.;McKnight, Barbara;Mozaffarian, Dariush
循环中的超长链饱和脂肪酸（VLSFAs）是饮食和代谢的综合生物标志物，可能为心力衰竭（HF）预防指明新的风险途径和潜在靶点。VLSFA在人类HF的协会是未知的。方法和结果使用队列研究设计，我们研究了连续测量血浆磷脂VLSFA与事件HF心血管健康研究的协会。我们使用考克斯回归分析研究了3种主要循环VLSFA（二十四烷酸（24：0）、二十二烷酸（22：0）和花生酸（20：0））随时间变化的水平与HF事件风险的关系。在45030人年的4249名参与者中，我们确定了1304例HF事件，包括489例射血分数保留和310例射血分数降低。校正主要HF危险因素和其他循环脂肪酸后，每种VLSFAs水平越高，发生HF的风险越低（P趋势
Background-Circulating very-long-chain saturated fatty acids (VLSFAs) are integrated biomarkers of diet and metabolism that may point to new risk pathways and potential targets for heart failure (HF) prevention. The associations of VLSFA to HF in humans are not known.Methods and Results-Using a cohort study design, we studied the associations of serially measured plasma phospholipid VLSFA with incident HF in the Cardiovascular Health Study. We investigated the associations of time-varying levels of the 3 major circulating VLSFAs, lignoceric acid (24:0), behenic acid (22:0), and arachidic acid (20:0), with the risk of incident HF using Cox regression. During 45030 person-years among 4249 participants, we identified 1304 cases of incident HF, including 489 with preserved and 310 with reduced ejection fraction. Adjusting for major HF risk factors and other circulating fatty acids, higher levels of each VLSFAs were associated with lower risk of incident HF (P trend