Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI - A case-control study
Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI - A case-control study
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DOI：
10.1161/hq1001.098463
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发表时间：
2001-10-01
影响因子：
8.7
通讯作者：
Brown, BG
中科院分区：
文献类型：
--
作者：
Zhao, XQ;Yuan, C;Brown, BG
高分辨率磁共振成像（MRI）与流动抑制不仅提供了有用的信息，管腔和壁面积的颈动脉，但也可以确定的主要组织成分的颈动脉粥样硬化斑块。在冠状动脉疾病（CAD）患者中检查强化降脂治疗对这些MRI组织特征的影响。在家族性动脉粥样硬化治疗研究（FATS）随访中，从60例接受强化降脂治疗（烟酸2.5 g/d、洛伐他汀40 mg/d和考来替泊20 g/d）10年的CAD患者中随机选择8例。选择8名年龄（+/-3岁）、基线低密度脂蛋白（+/-5 mg/dL）和甘油三酯（+/-50 mg/dL）与接受治疗的患者相匹配但从未接受过降脂药物治疗的CAD患者作为对照组。对于这32个颈动脉中的每一个，在盲法方案中，通过面积测量法从显示大多数斑块的磁共振图像测量管腔和斑块面积。根据既定标准鉴别纤维组织、钙和脂质沉积。斑块组成估计为总planimetered面积的一部分。与对照组相比，接受10年强化降脂治疗的患者的低密度脂蛋白胆固醇水平显著降低（分别为84和158 mg/dL; P
High-resolution magnetic resonance imaging (MRI) with flow suppression not only provides useful information on luminal and wall areas of the carotid artery but also can identify the principal tissue components of the carotid atherosclerotic plaque. The effects of intensive lipid-lowering therapy on these MRI tissue characteristics were examined in patients with coronary disease (CAD). Eight CAD patients who have been receiving intensive lipid-lowering treatment (niacin 2.5 g/d, lovastatin 40 mg/d, and colestipol 20 g/d) for 10 years in the Familial Atherosclerosis Treatment Study (FATS) follow-up were randomly selected from among 60 such treated patients. Eight CAD patients who were matched to the treated patients for age (+/-3 years), baseline low density lipoprotein (+/-5 mg/dL), and triglycerides (+/- 50 mg/dL) but who had never been treated with lipid-lowering drugs were selected as controls. For each of these 32 carotid arteries, luminal and plaque areas were measured by planimetry, in a blinded protocol, from the magnetic resonance image that showed most plaque. Fibrous tissue, calcium, and lipid deposits were identified on the basis of established criteria. Plaque composition was estimated as a fraction of total planimetered area. Patients treated with 10-year intensive lipid-lowering therapy, compared with control subjects, had significantly lower low density lipoprotein cholesterol levels (84 versus 158 mg/dL, respectively; P