Mechanism of long slender (LS) to short stumpy (SS) transformation in the African trypanosomes.
Mechanism of long slender (LS) to short stumpy (SS) transformation in the African trypanosomes.
复制标题
非洲锥虫从细长（LS）向短粗（SS）转变的机制。
DOI：
10.1111/j.1550-7408.1989.tb01099.x
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
J. Sechelski
中科院分区：
文献类型：
--
作者：
J. Seed;J. Sechelski
非洲锥虫的细长到短的短的阶段的转变是锥虫生命周期的重要组成部分。四个可能的机制，可以控制这一事件进行了调查。已经表明，（a）分裂的细长到不分裂的短的转变不是锥虫生命周期中的程序化事件;（B）它似乎也不是由某种形式的细胞与细胞接触抑制生长而启动的。此外，有证据表明，（c）过渡不是由锥虫生长过程中环境中的关键生长营养素耗尽开始的。考虑的最后一种可能性（d）是在锥虫生长期间，生长因子-短截短诱导物在锥虫环境中积累。有证据表明，感染动物的血浆可以抑制锥虫掺入胸苷。这些数据与外源性生长抑制剂在感染期间积累的建议一致。
The transformation of the long slender to the short stumpy stages of the African trypanosomes is an essential part of the trypanosome life cycle. Four possible mechanisms which could control this event have been investigated. It has been shown that (a) the dividing long slender to non-dividing short stumpy transition is not a programmed event in the trypanosome life cycle; nor (b) would it appear to be initiated by some form of cell to cell contact inhibition of growth. In addition, evidence is presented which would suggest that (c) the transition is not started by the depletion of a critical growth nutrient from the environment during the growth of the trypanosomes. The last possibility (d) considered is that during trypanosome growth, a growth inhibitor-short stumpy inducer accumulates in the trypanosomes' environment. Evidence is presented which shows that plasma from infected animals can inhibit the incorporation of thymidine by the trypanosomes. These data are consistent with the suggestion of an exogenous growth inhibitor accumulating during the infection.
DL-α-二氟甲基鸟氨酸化疗后抗体在消除锥虫中的作用。
DOI：
--
发表时间：
1983
期刊：
The Journal of parasitology
影响因子：
--
作者：
deGee,AL;McCann,PP;Mansfield,JM
通讯作者：
Mansfield,JM
抑制体内多胺生物合成后布氏锥虫罗得西亚的形态变化。
影响因子：
2.6
作者：
deGee,AL;Carstens,PH;McCann,PP;Mansfield,JM
通讯作者：
Mansfield,JM