Onboard functional and molecular imaging: a design investigation for robotic multipinhole SPECT.
Onboard functional and molecular imaging: a design investigation for robotic multipinhole SPECT.
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机载功能和分子成像：机器人多针孔 SPECT 的设计研究。
DOI：
10.1118/1.4845195
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发表时间：
2014
期刊：
影响因子：
3.8
通讯作者：
Yin,Fang-Fang
中科院分区：
文献类型：
--
作者：
Bowsher,James;Yan,Susu;Roper,Justin;Giles,William;Yin,Fang-Fang
目的：机载成像目前主要通过X射线传输方式进行，在现代放射治疗中是必不可少的。随着放射治疗走向个性化医疗，观察个体基因表达的分子成像也可能在船上发挥重要作用。核医学方法，如单光子发射计算机断层扫描(SPECT)，是分子成像的主要方式。本研究的目的是探讨一种用于SPECT的机器人多针孔方法。方法：通过计算机辅助设计(CAD)研究，评估操纵SPECT机器人系统的可行性。为了获得快速、高质量的SPECT图像，设计了一台49针孔SPECT相机，它可以对感兴趣的成像区域发出的光子提供高灵敏度。对这种多针孔系统进行了计算机模拟研究。在一个仰卧式女性体模的乳房区域放置了17个直径分别为10 mm和7 mm的热点。热点活性浓度是背景的6倍。对于49针孔相机和参考的更传统的大视场(FOV)SPECT系统，计算机模拟投影数据进行4分钟扫描并重建SPECT图像。使用非预白化强制选择数值观察器对热点定位进行评估。结果：CAD模拟研究发现，机器人可以操控SPECT摄像机，使患者处于放射治疗的位置。在成像研究中，大多数热点在49个针孔图像中都很明显。对于10 mm和7 mm直径的热点，49针孔系统的平均定位误差分别为0.4 mm和1.7 mm，参考Bide-FOV系统的平均定位误差分别为3.1 mm和5.7 mm。结论：机器人可以操纵多针孔SPECT系统在患者的位置进行放射治疗。该系统可以提供机载功能和分子成像，扫描时间为4分钟。
Purpose:Onboard imaging—currently performed primarily by x‐ray transmission modalities—is essential in modern radiation therapy. As radiation therapy moves toward personalized medicine, molecular imaging, which views individual gene expression, may also be important onboard. Nuclear medicine methods, such as single photon emission computed tomography (SPECT), are premier modalities for molecular imaging. The purpose of this study is to investigate a robotic multipinhole approach to onboard SPECT.Methods:Computer‐aided design (CAD) studies were performed to assess the feasibility of maneuvering a robotic SPECT system about a patient in position for radiation therapy. In order to obtain fast, high‐quality SPECT images, a 49‐pinhole SPECT camera was designed which provides high sensitivity to photons emitted from an imaging region of interest. This multipinhole system was investigated by computer‐simulation studies. Seventeen hot spots 10 and 7 mm in diameter were placed in the breast region of a supine female phantom. Hot spot activity concentration was six times that of background. For the 49‐pinhole camera and a reference, more conventional, broad field‐of‐view (FOV) SPECT system, projection data were computer simulated for 4‐min scans and SPECT images were reconstructed. Hot‐spot localization was evaluated using a nonprewhitening forced‐choice numerical observer.Results:The CAD simulation studies found that robots could maneuver SPECT cameras about patients in position for radiation therapy. In the imaging studies, most hot spots were apparent in the 49‐pinhole images. Average localization errors for 10‐mm‐ and 7‐mm‐diameter hot spots were 0.4 and 1.7 mm, respectively, for the 49‐pinhole system, and 3.1 and 5.7 mm, respectively, for the reference broad‐FOV system.Conclusions:A robot could maneuver a multipinhole SPECT system about a patient in position for radiation therapy. The system could provide onboard functional and molecular imaging with 4‐min scan times.