ACUMENTIN, A PROTEIN IN MACROPHAGES WHICH CAPS THE POINTED END OF ACTIN-FILAMENTS
ACUMENTIN, A PROTEIN IN MACROPHAGES WHICH CAPS THE POINTED END OF ACTIN-FILAMENTS
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DOI：
10.1038/297303a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
HARTWIG, JH
中科院分区：
文献类型：
--
作者：
SOUTHWICK, FS;HARTWIG, JH
巨噬细胞[兔肺]有一种钙不敏感蛋白，它结合并抑制肌动蛋白丝尖端的单体添加，肌动蛋白丝被标记为重肌球蛋白。这种蛋白，与钙敏感蛋白一致，已经被证明可以结合丝的倒刺端，可以导致细胞质中肌动蛋白丝长度的完全控制。无论是低钙浓度还是高钙浓度，肌动蛋白丝末端的阻断都会阻止活细胞的“跑步”。还研究了人的粒细胞。
Macrophages [rabbit lung] have a Ca-insensitive protein which binds to and inhibits monomer addition at the pointed end of actin filaments labeled with heavy meromyosin. This protein, in concert with Ca-sensitive proteins already shown to bind the barbed end of filaments, can lead to complete control of actin filament length in the cytoplasm. The blocking of actin filament ends in low as well as high Ca concentrations would prevent treadmilling in living cells. Human granulocytes were also studied.