Sustained release of antibiotic from poly(2-hydroxyethyl methacrylate) to prevent blinding infections after cataract surgery.
Sustained release of antibiotic from poly(2-hydroxyethyl methacrylate) to prevent blinding infections after cataract surgery.
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DOI：
10.1016/j.biomaterials.2009.06.047
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发表时间：
2009-10
期刊：
影响因子：
14
通讯作者：
Ratner, Buddy D.
中科院分区：
文献类型：
--
作者：
Anderson, Erin M.;Noble, Misty L.;Garty, Shai;Ma, Hongyan;Bryers, James D.;Shen, Tueng T.;Ratner, Buddy D.
在发达国家，白内障的主要治疗方法是在混浊的自然透镜摘除后植入人工透镜。白内障手术通常被认为是安全的，但在先进的无菌手术室并不普遍的国家，白内障手术会带来很大的风险。术后感染（眼内炎）是一种潜在的致盲并发症。感染通常由新透镜植入物的细菌定殖和随后的耐抗生素生物膜形成引起。为了对抗这种风险，我们开发了一种聚合物水凝胶系统，该系统可以在眼睛的地球仪内长时间递送有效水平的抗生素。将诺氟沙星™抗生素加载到交联的聚（甲基丙烯酸2-羟乙酯）（pHEMA）凝胶中，随后用异氰酸十八烷基酯对其进行表面改性以产生控制诺氟沙星释放的疏水限速屏障。采用扫描电子显微镜（SEM）和X射线光电子能谱（XPS）对十八烷基表面改性进行了表征。15分钟的修饰导致均匀的表面涂层和诺氟沙星从基质中的近零级释放。从包被的pHEMA释放的诺氟沙星杀死悬浮液中和模拟医疗植入物表面上的表皮葡萄球菌。通过这些数据，我们证明了一种新的和有效的系统，用于从水凝胶基质中持续释放药物，并具体应用于眼内透镜手术。
Intraocular lens implantation after opacified natural lens removal is the primary treatment for cataracts in developed countries. Cataract surgery is generally considered safe, but entails significant risks in countries where sophisticated sterile operating theaters are not widely available. Post-operative infection (endophthalmitis) is a potential blinding complication. Infection often results from bacterial colonization of the new lens implant and subsequent antibiotic-tolerant biofilm formation. To combat this risk, we developed a polymeric hydrogel system that can deliver effective levels of antibiotic over an extended period of time within the globe of the eye. Norfloxacin™ antibiotic was loaded into cross-linked poly(2-hydroxyethyl methacrylate) (pHEMA) gels, which were subsequently surface-modified with octadecyl isocyanate to produce a hydrophobic rate-limiting barrier controlling norfloxacin release. Octadecyl surface modification was characterized using scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). A 15-min modification leads to a uniform surface coating and near zero order release of norfloxacin from the matrix. Norfloxacin released from coated pHEMA kills Staphylococcus epidermidis in suspension and on a simulated medical implant surface. With these data, we demonstrate a new and effective system for sustained drug release from a hydrogel matrix with specific application for intraocular lens surgery.
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DOI：
10.1007/s10856-005-5954-2
发表时间：
2005-02-01
影响因子：
3.7
作者：
Tsou, TL;Tang, ST;Wang, HJ
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64.8
作者：
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通讯作者：
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影响因子：
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作者：
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Stoodley, P