Drug versus non-drug behaviors: A dual-reward model of sex differences and neurobiological mechanisms in rats.
Drug versus non-drug behaviors: A dual-reward model of sex differences and neurobiological mechanisms in rats.
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药物与非药物行为：大鼠性别差异和神经生物学机制的双重奖励模型。
DOI：
10.1002/jeab.752
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发表时间：
2022
影响因子：
2.7
通讯作者：
Kalivas,PeterW
中科院分区：
文献类型：
--
作者：
Nall,RustyW;Chalhoub,RedaM;Kalivas,PeterW
Substance Use Disorders (SUDs) are an impactful problem characterized by chronic relapse and engagement in drug‐related behaviors at the expense of non‐drug behaviors. Brain regions implicated in drug and non‐drug‐related behaviors often overlap, complicating investigations of neurobiological mechanisms underlying SUDs. Here we presented a within‐subject model for studying self‐administration, reinforcer competition, extinction, and cued reinstatement of cocaine‐ and food‐seeking in rats. Due to differences in cocaine‐ and food‐reinforced behavior, we transformed data to proportions of baseline, revealing increased resistance to extinction and disproportionately greater cued reinstatement of cocaine seeking relative to food seeking. Consistent with previous reports, females showed greater preference for cocaine reinforcement than males, though these findings failed to reach statistical significance. To demonstrate the model's utility for investigating neurobiological mechanisms, we included proof‐of‐concept calcium imaging data demonstrating the utility of the behavioral model for detecting cellular activity patterns associated with cocaine‐ and food‐seeking behaviors. Future studies utilizing this model should improve understanding of the development and expression of pathological behaviors characteristic of SUDs in humans, sex differences in these behaviors, and their neurobiological correlates. Thus, the model has utility for improving understanding of SUDs, leading to novel treatments to reduce the pathological behaviors associated with SUDs.
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可卡因寻求行为：与食物寻求行为和潜在治疗的比较
影响因子：
2.7
作者：
B. Tunstall;D. Kearns
通讯作者：
D. Kearns
影响因子：
8.3
作者：
Becker JB
通讯作者：
Becker JB
影响因子：
3.4
作者：
Allain, Florence;Bouayad-Gervais, Karim;Samaha, Anne-Noel
通讯作者：
Samaha, Anne-Noel
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1111/j.1460-9568.2012.08024.x
发表时间：
2012-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Cameron CM;Carelli RM
通讯作者：
Carelli RM