The chronobiology of human cytokine production.
The chronobiology of human cytokine production.
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DOI：
10.3109/08830189809043012
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发表时间：
1998-01-01
影响因子：
5
通讯作者：
Harrison, L C
中科院分区：
文献类型：
--
作者：
Petrovsky, N;Harrison, L C
人全血中细胞因子的产生具有昼夜节律性。促炎细胞因子干扰素-γ、肿瘤坏死因子-α、白介素1和白介素12的产生高峰出现在夜间和清晨，此时血浆皮质醇水平最低。血浆皮质醇和皮质醇的产生之间存在因果关系，这一发现表明，服用醋酸可的松使血浆皮质醇在生理范围内升高，导致促炎细胞因子的产生相应下降。皮质醇可能不是唯一引起细胞因子节律的神经内分泌激素；其他候选激素包括17-羟孕酮、褪黑素和二氢表雄烯二酮(DHEAS)。细胞因子昼夜节律的发现可能有助于理解类风湿性关节炎或哮喘等免疫炎症疾病为什么会在夜间或清晨恶化，并有助于优化这些疾病的治疗。细胞因子产生的昼夜节律性也对抽取血液样本进行诊断T细胞分析的时间有影响。最后，免疫功能的昼夜节律性表明，免疫反应的性质，例如对接种疫苗的反应，可能会被抗原注射的时间所改变，并增加了通过联合注射免疫调节激素(如糖皮质激素)来治疗操纵免疫反应的可能性。
Cytokine production in human whole blood exhibits diurnal rhythmicity. Peak production of the pro-inflammatory cytokines IFN-gamma, TNF-alpha, IL-1 and IL-12 occurs during the night and early morning at a time when plasma cortisol is lowest. The existence of a causal relationship between plasma cortisol and production is suggested by the finding that elevation of plasma cortisol within the physiological range by the administration of cortisone acetate results in a corresponding fall in pro-inflammatory cytokine production. Cortisol may not be the only neuroendocrine hormone that entrains cytokine rhythms; other candidates include 17-hydroxy progesterone, melatonin and dihydroepiandrostene dione (DHEAS). The finding of diurnal cytokine rhythms may be relevant to understanding why immuno-inflammatory disorders such as rheumatoid arthritis or asthma exhibit night-time or early morning exacerbations and to the optimisation of treatment for these disorders. Diurnal rhythmicity of cytokine production also has implications for the timing of blood samples drawn for diagnostic T-cell assays. Finally, diurnal rhythmicity of immune function suggests that the nature of an immune response, for example in response to vaccination, may be modified by the time of day of antigen administration and raises the possibility that immune responses could be therapeutically manipulated by co-administration of immuno-regulatory hormones such as glucocorticoids.